Evidence map›Paper›PMID 40238651›Full record

ArticleeLife2025

Functional characterization of all

Hirokazu Kimura, Kamel Lahouel, Cristian Tomasetti, Nicholas Jason Roberts

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Hirokazu KimuraDepartment of Pathology, the Johns Hopkins University School of Medicine, Baltimore, United States.
Kamel LahouelDivision of Integrated Genomics, Translational Genomics Research Institute, Phoenix, United States.
Cristian TomasettiDivision of Integrated Genomics, Translational Genomics Research Institute, Phoenix, United States.
Nicholas Jason RobertsDepartment of Pathology, the Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-8709-0664

Funding

Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI JAFFEE, ELIZABETH M. · 1993 to 2022
$54.6M
Japanese Society of Gastroenterology Support for Young Gastroenterologists Studying in the United StatesJapan Society for the Promotion of Science Overseas Research FellowshipsNCI NIH HHS P50 CA062924NCI NIH HHS P50CA62924
6 · The paper itself

Abstract

Interpretation of variants identified during genetic testing is a significant clinical challenge. In this study, we developed a high-throughput CDKN2A functional assay and characterized all possible human

Indexed as

Cyclin-Dependent Kinase Inhibitor p16Mutation, MissenseComputational BiologyComputer SimulationHumansCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16assaycancercancer biologyfunctionalgeneticsgenomicshumanmissensepredictorsvariants

Identifiers

PMID40238651
PMCPMC12002794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.