Evidence map›Paper›PMID 40238626›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Ruthenium Catalyzed Ortho-Arylation Reaction of Benzoic Acids with Arylthianthrenium Salts.

Kaiping Wang, Xiaowen Teng, Duo Zhang, Bingxin Xu, Pan Gao, Shuli Wang, Shuwei Zhang, Lukas J Gooßen, Feng Chen, Guodong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaiping Wang *School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Xiaowen Teng *School of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Duo Zhang *Medicine Center, Guangxi University of Science and Technology, Liushi Road 257, Liuzhou, 545006, China.
Bingxin XuMedicine Center, Guangxi University of Science and Technology, Liushi Road 257, Liuzhou, 545006, China.
Pan GaoSchool of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Shuli WangSchool of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Shuwei ZhangSchool of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Lukas J GooßenFakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätsstr. 150, 44801, Bochum, Germany.
Feng ChenSchool of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.
Guodong ZhangSchool of Chemistry and Chemical Engineering, Yangzhou University, Siwangting Road 180, Yangzhou, 225002, China.

Funding

Deutsche Forschungsgemeinschaft 2033-390677874Natural Science Foundation of Jiangsu Province BK20200943Science and Technology BaseTalent Special Project of Guangxi AD21220087
6 · The paper itself

Abstract

Arylthianthrenium salts have become key intermediates for late-stage functionalizations of drug-like molecules. Ruthenium-phosphine catalysts are now shown to enable their use as aryl sources in high-yielding ortho-C─H arylations of benzoic acids. The arylthianthrenium salts are converted chemo-selectively, leaving aryl halides and boronates untouched. The carboxylate groups are uniquely effective as directing groups, ensuring exclusive ortho-selectivity even in the presence of competing pyridine or amide groups. This makes the reaction orthogonal to cross-couplings and conventional C─H arylations. The carboxylate group can be removed via decarboxylation or serve as an anchor for downstream transformations. Mechanistic studies identify C─H ruthenation as the rate-limiting step and highlight the unique efficiency of P(Cy)₃ ligands.

Indexed as

Aromatic carboxylatesArylthianthrenium saltsC─H arylationDecarboxylationRuthenium

Identifiers

PMID40238626
PMCPMC12184312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.