Evidence map›Paper›PMID 40238461›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Peripheral CD4

Rui Xiong, Yinyin Hu, Menghan Wang, Ting Han, Yuying Hu, Chaolin Ma, Baoming Li

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Neurodevelopmental effects of early life stress: PFC and cognition.Neuroscience and biobehavioral reviews · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rui XiongInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0009-4264-8685
Yinyin HuInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0003-4933-7261
Menghan WangInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0001-5785-351X
Ting HanInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0007-6649-5658
Yuying HuInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0001-8364-7816
Chaolin MaInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0000-0002-1202-5649
Baoming LiInstitute of Life Science and School of Life Science, Nanchang University, Nanchang 330031, China.ORCID 0009-0006-1554-9700

Funding

Ministry of Science and Technology of the People's Republic of China (MOST) 2021ZD0201705MOST | National Natural Science Foundation of China (NSFC) 31771182MOST | National Natural Science Foundation of China (NSFC) 31971035
6 · The paper itself

Abstract

Maternal separation (MS), a chronic stress event in early life, impairs myelination in the prefrontal cortex (PFC) and leads to PFC cognitive disorders. It remains largely unclear how such deficits are mediated. Here, we show that peripheral CD4

Indexed as

CD4-Positive T-LymphocytesCognitionMaternal DeprivationMyelin SheathPrefrontal CortexAnimalsFemaleMaleMiceMice, Inbred C57BLMice, KnockoutOligodendrogliaStress, PsychologicalCD4+ T cellscognitive functionmaternal separationmyelinationprefrontal cortex

Identifiers

PMID40238461
PMCPMC12037062

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.