Evidence map›Paper›PMID 40238456›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A single mutation in an enteric virus alters tropism and sensitivity to microbiota.

Andrea K Erickson, Danica M Sutherland, Olivia L Welsh, Robert W Maples, Terence S Dermody, Julie K Pfeiffer

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Journal of virology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Andrea K EricksonDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-3739-5440
Danica M SutherlandDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.ORCID 0000-0001-9328-4994
Olivia L WelshDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.ORCID 0000-0002-8039-7807
Robert W MaplesDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5815-1210
Terence S DermodyDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224.ORCID 0000-0003-1853-8741
Julie K PfeifferDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-2973-4895

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
The influence of host barriers on viral quasispecies diversity and pathogenesisR01AI074668 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI PFEIFFER, JULIE K · 2008 to 2022
$6.0M
Circadian control of enteric virus infectionR01AI158351 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI PFEIFFER, JULIE K · 2021 to 2025
$2.9M
Reovirus NeuropathogenesisR01AI174526 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TERENCE S. DERMODY · 2022 to 2026
$2.7M
Enteric virus-microbiota interactionsR37AI074668 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Julie K Pfeiffer · 2023 to 2026
$2.5M
Spinning Disk Confocal for UT SouthwesternS10OD028630 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2020 to 2020
$600k
NCI NIH HHS P30 CA142543NIAID NIH HHS R01 AI074668NIAID NIH HHS R01 AI158351NIAID NIH HHS R01 AI174526NIAID NIH HHS R37 AI074668NIAID NIH HHS T32 AI005284NIH HHS S10 OD028630
6 · The paper itself

Abstract

Many enteric viruses benefit from the microbiota. In mice, microbiota depletion reduces infection by noroviruses and picornaviruses. However,

Indexed as

Gastrointestinal MicrobiomeMicrobiotaMutationReoviridae InfectionsViral TropismAnimalsHumansMiceVirus Replicationenteric virusinterferonmicrobiotareovirussialic acid

Identifiers

PMID40238456
PMCPMC12037040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.