Evidence map›Paper›PMID 40238076›Full record

ArticleJournal of endocrinological investigation2025

Intracystic catecholamine variations in cystic pheochromocytoma.

Tomoko Fujii, Hironori Bando, Masaaki Yamamoto, Maki Kanzawa, Keitaro Kanie, Shin Urai, Yasutaka Tsujimoto, Fumikazu Sawabe, Keiko Fukazawa, Asa Hanayama and 4 more

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tomoko FujiiDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Hironori BandoDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan. hbando@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0002-7421-2714
Masaaki YamamotoDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Maki KanzawaDepartment of Diagnostic Pathology, Kobe University Hospital, Kobe, Japan.
Keitaro KanieDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Shin UraiDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Yasutaka TsujimotoDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Fumikazu SawabeDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Keiko FukazawaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Asa HanayamaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Tomoko YamadaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Kei YoshinoDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Hidenori FukuokaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Wataru OgawaDivision of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Funding

Japan Society for the Promotion of Science 21KK0149
6 · The paper itself

Abstract

purposeApproximately 20% of pheochromocytomas are cystic in nature. However, research on the correlation between catecholamine and metanephrine fractions in cystic fluid and peripheral blood is limited. This study investigated the relationship between catecholamine fractions and their metabolites in peripheral blood and cystic fluid.

methodsFive patients with pathologically diagnosed cystic pheochromocytomas were included in the analysis. Catecholamine fractions and their metabolites in the cystic fluid were measured. The relationship between phenylethanolamine N-methyltransferase (PNMT) expression in tumor tissues and catecholamine fractions of cystic fluid was also assessed.

resultsThe elevated patterns of catecholamine and metanephrine fractions in the cystic fluid were consistent with those observed in the peripheral blood of two patients. However, in two other patients. discordance was observed, with normetanephrine predominance in the peripheral blood despite adrenaline/metanephrine and noradrenaline/normetanephrine elevations in the cystic fluid. Immunohistochemical analysis revealed that PNMT expression in tumor tissues and the elevated pattern of catecholamine fractions in the peripheral blood were consistent in all patients, except for one patient with non-elevated peripheral blood catecholamines. However, in cystic fluid, the predominantly catecholamine fraction did not consistently align with PNMT expression.

conclusionIn cystic pheochromocytoma, the elevation patterns of catecholamine fractions in cysts may not align with those in the peripheral blood and may differ relative to PNMT expression in tumor tissues.

Indexed as

Adrenal Gland NeoplasmsCatecholaminesCyst FluidCystsPheochromocytomaAdultAgedFemaleHumansMaleMetanephrineMiddle AgedPhenylethanolamine N-MethyltransferaseCatecholaminesMetanephrinePhenylethanolamine N-MethyltransferaseCatecholamineCystic pheochromocytomaPhenylethanolamine N-methyltransferase

Identifiers

PMID40238076

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.