Evidence map›Paper›PMID 40238020›Full record

ArticleThe ultrasound journal2025

Contrast-ultrasound dispersion imaging for renal cell carcinoma diagnostics.

Peiran Chen, Simona Turco, Zhaohan Liu, Christiaan Widdershoven, Jorg Oddens, Hessel Wijkstra, Massimo Mischi, Patricia Zondervan

Abstract read
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In one paragraph

Article in The ultrasound journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peiran ChenDepartment of Electrical Engineering, Eindhoven University of Technology, De Groene Loper 19, Eindhoven, 5612 AP, the Netherlands. p.chen1@tue.nl.
Simona TurcoDepartment of Electrical Engineering, Eindhoven University of Technology, De Groene Loper 19, Eindhoven, 5612 AP, the Netherlands.
Zhaohan LiuDepartment of Electrical Engineering, Eindhoven University of Technology, De Groene Loper 19, Eindhoven, 5612 AP, the Netherlands.
Christiaan WiddershovenDepartment of Urology, Amsterdam University Medical Centers, De Boelelaan 1117, Amsterdam, 1081 HV, the Netherlands.
Jorg OddensDepartment of Urology, Amsterdam University Medical Centers, De Boelelaan 1117, Amsterdam, 1081 HV, the Netherlands.
Hessel WijkstraDepartment of Electrical Engineering, Eindhoven University of Technology, De Groene Loper 19, Eindhoven, 5612 AP, the Netherlands.
Massimo MischiDepartment of Electrical Engineering, Eindhoven University of Technology, De Groene Loper 19, Eindhoven, 5612 AP, the Netherlands.
Patricia ZondervanDepartment of Urology, Amsterdam University Medical Centers, De Boelelaan 1117, Amsterdam, 1081 HV, the Netherlands.

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 15282
6 · The paper itself

Abstract

Cost-effective screening methods for Renal Cell Carcinoma (RCC) are still lacking. Angiogenesis is a recognized hallmark of cancer growth, leading to distinguishable perfusion patterns in tumors from those in normal tissue. This establishes the basis for diagnostic imaging solutions by dynamic contrast-enhanced ultrasound (DCE-US). In the past years, we have developed contrast-ultrasound dispersion imaging (CUDI) techniques to quantify prostate DCE-US acquisitions, obtaining promising results for prostate cancer localization. In this pilot study, we investigated for the first time its feasibility for RCC localization. DCE-US acquisitions of the kidney in 5 patients were used to perform CUDI analysis. With the obtained CUDI parameters and the delineated tumor and parenchyma regions, we performed pixel-based classification, from which the highest area under the receiver-operating-characteristic curve (AUC) = 0.96 was obtained for an individual patient, and an average AUC = 0.68 was obtained for the full patient dataset, showing the potential of CUDI for solid RCC localization. Further validation in a larger dataset and evaluation of the compatibility of point-of-care diagnosis are required.

Indexed as

AngiogenesisContrast-ultrasound dispersion imagingDynamic contrast-enhanced ultrasoundRenal cell carcinoma diagnosticsUrology

Identifiers

PMID40238020
PMCPMC12003236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.