Evidence map›Paper›PMID 40237949›Full record

ArticleMolecular neurobiology2025

Inhibiting SNX14 Alleviates Epileptic Seizures by Regulating GluA2 Degradation via the Lysosomal Pathway.

Wang Jing, Cao Qingqing, Yan Xia, Qin Ningxiang, Xu Demei, Wang Xuefeng, Ai Ming, Peng Xi, Wang Liang

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Optimized Preparation ofCurrent issues in molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wang Jing *Department of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cao Qingqing *Department of Neurology, Bishan Hospital of Chongqing Medical University, Bishan Hospital of Chongqing, Chongqing, China.
Yan XiaDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qin NingxiangDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xu DemeiDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang XuefengDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ai MingDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Peng XiDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. px5523@126.com.
Wang LiangDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. wang0128_0@163.com.

Funding

Chongqing Postdoctoral Program Funding in 2020 and Program for Youth Innovation in Future Medicine, Chongqing Medical University W0138High-Level Medical Reserved Personnel Training Project of Chongqing 2020GDRC019National Natural Science Foundation of China 82101517
6 · The paper itself

Abstract

Epilepsy is a common chronic neurological condition, and temporal lobe epilepsy (TLE) is the most common form of refractory epilepsy. However, the underlying causes of TLE remain unclear. Our initial findings revealed that the expression of sorting nexin 14 (SNX14), which is a member of the sorting nexin protein family, was significantly upregulated in brain tissues from both patients with TLE and mouse models of TLE. Moreover, modulation of SNX14 expression in the hippocampus of mice demonstrated that SNX14 downregulation significantly decreased the susceptibility to and severity of seizures, whereas SNX14 overexpression exerted the opposite effects. Mechanistically, we revealed that GluA2, which is a subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor, was a downstream target of SNX14. Further studies indicated that SNX14 modulated GluA2 protein levels by regulating GluA2 degradation via the lysosomal pathway, which in turn influenced glutamatergic synaptic transmission. In conclusion, our findings suggest that the SNX14-GluA2 pathway could be a promising target for the development of novel treatments for epilepsy.

Indexed as

LysosomesProteolysisReceptors, AMPASeizuresSignal TransductionSorting NexinsAnimalsEpilepsy, Temporal LobeFemaleHippocampusHumansMaleMiceMice, Inbred C57BLglutamate receptor ionotropic, AMPA 2Receptors, AMPASorting NexinsEpilepsyGluN2BProteasome pathwayUBQLN4

Identifiers

PMID40237949

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.