Evidence map›Paper›PMID 40237942›Full record

ReviewDiscover oncology2025

Immune microenvironment and molecular mechanisms in endometrial cancer: implications for resistance and innovative treatments.

Yijia Chen, Lai Jiang, Lanyue Zhang, Hao Chi, Qin Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yijia ChenClinical Medical College, Southwest Medical University, Luzhou, 646000, China.
Lai JiangClinical Medical College, Southwest Medical University, Luzhou, 646000, China.
Lanyue ZhangClinical Medical College, Southwest Medical University, Luzhou, 646000, China.
Hao ChiClinical Medical College, Southwest Medical University, Luzhou, 646000, China. chihao7511@163.com.
Qin WangSichuan Provincial Center for Gynecology and Breast Diseases (Gynecology), Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China. Wangq@swmu.edu.cn.

Funding

Sichuan Province Science and Technology Department of foreign (border) high-end talent introduction project 2023ZHYZ0009
6 · The paper itself

Abstract

This review provides a systematic overview of the molecular mechanisms of endometrial cancer and its drug resistance, particularly involving the aberrant activation of some key signaling pathways. These molecular mechanisms significantly affect the therapeutic outcome of endometrial cancer by promoting tumor cell proliferation, anti-apoptosis, and drug resistance. The article also analyzes the critical role of the immune microenvironment in cancer drug resistance, focusing on the impact of immune cells, immune checkpoints, and hypoxic metabolic reprogramming on anticancer therapies. In recent years, immunotherapy and individualized therapy have shown promising clinical outcomes, especially in advanced endometrial cancer. This article summarizes recent advances in related therapeutic strategies and proposes emerging therapeutic strategies by targeting key pathways and modulating the immune microenvironment to overcome drug resistance and improve patient prognosis.

Indexed as

Drug resistanceEndometrial cancerImmune checkpoint inhibitorsImmunotherapyMolecular mechanismsPrecision medicineTumor microenvironment

Identifiers

PMID40237942
PMCPMC12003227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.