Evidence map›Paper›PMID 40237939›Full record

ReviewEnvironmental monitoring and assessment2025

Endocrine-disrupting pesticide exposure relevant to reproductive health: a case study from Costa Rica.

Navilla Apú, François Rommes, Maricruz Alvarado-Arias, Michael Méndez-Rivera, Verónica Lizano-Fallas

Abstract readReview
In one paragraph

Review in Environmental monitoring and assessment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Navilla ApúInstituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José, 2060, Costa Rica.
François RommesDépartement Agronomique, Haute Ėcole Charlemagne Huy, Huy, 4500, Belgium.
Maricruz Alvarado-AriasCentro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, San José, 2060, Costa Rica.
Michael Méndez-RiveraCentro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, San José, 2060, Costa Rica.
Verónica Lizano-FallasCentro de Investigación en Contaminación Ambiental (CICA), Universidad de Costa Rica, San José, 2060, Costa Rica. veronica.lizanofallas@ucr.ac.cr.

Funding

International Training in Environmental Health over the LifespanD43TW011403 · FIC · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLAUDIO, LUZ · 2020 to 2024
$1.3M
FIC NIH HHS D43 TW011403Icahn School of Medicine at Mount Sinai International Training in Environmental Health over the LifespanUniversidad de Costa Rica PUBLICARE II-2024
6 · The paper itself

Abstract

Global pesticide use has increased significantly over the past decade, leading to greater exposure to contaminants and associated health risks. Endocrine-disrupting pesticides have gained attention due to their strong association with human reproductive impairments and rising global infertility rates. In Costa Rica, studies have reported reduced fertility among agricultural workers and a higher prevalence of male infertility in regions with intensive pesticide use. However, the prioritization of pesticides detected in human fluids, based on their potential impact on reproductive health, has not been conducted. Here, analyzing human biomonitoring studies in the country over the last 25 years, 13 pesticides were identified and prioritized. Mancozeb ranked highest (14.8%), followed by dieldrin (12.1%) and chlorothalonil (12.0%). Eight criteria were used for prioritization, with non-carcinogenic risk, reported reproductive effects, and endocrine disruptor classification as key factors. This comprehensive approach highlights how multiple criteria collectively inform pesticide prioritization in relation to reproductive health risks. The findings indicated that while Costa Rica is a regional leader in pesticide biomonitoring, significant gaps remain, including limited data on unstudied pesticides and general population exposures. Establishing robust biomonitoring programs and public health surveillance systems to generate updated data and support evidence-based prevention policies is recommended. Additionally, the results of this study provide a valuable framework for guiding future research on the potential effects of pesticide mixtures.

Indexed as

Endocrine DisruptorsEnvironmental ExposureEnvironmental PollutantsPesticidesReproductive HealthCosta RicaEnvironmental MonitoringFemaleHumansMaleOccupational ExposureEndocrine DisruptorsEnvironmental PollutantsPesticidesEndocrine disruptorsHuman biomonitoringHuman reproductive healthPesticide prioritizationPesticidesRisk assessment

Identifiers

PMID40237939
PMCPMC12003610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.