Evidence map›Paper›PMID 40237920›Full record

ArticleOral and maxillofacial surgery2025

Prevalence of MRONJ in patients treated with antiresorptive agents for glucocorticoid-induced osteoporosis.

Hidenobu Sakuma, Hiroko Kanemaru, Akira Kurokawa, Marie Soga, Moe Yamashita, Mai Nozawa-Kobayashi, Kanae Niimi, Tadaharu Kobayashi

Abstract read
PubMed Publisher
In one paragraph

Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hidenobu SakumaDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho, Niigata City, 951-8514, Japan. h-sakuma@dent.niigata-u.ac.jp.
Hiroko KanemaruOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Akira KurokawaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Marie SogaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Moe YamashitaOral Management Clinic for Medical Cooperation, Niigata University Medical and Dental Hospital, Niigata, Japan.
Mai Nozawa-KobayashiDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho, Niigata City, 951-8514, Japan.
Kanae NiimiPatient Support Center, Niigata University Medical and Dental Hospital, Niigata, Japan.
Tadaharu KobayashiDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho, Niigata City, 951-8514, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study, we aimed to investigate the incidence of medication-related osteonecrosis of the jaw (MRONJ) in patients with glucocorticoid-induced osteoporosis (GIOP) and to examine risk factors for MRONJ development, as well as the preventive effect of tooth extraction before antiresorptive agent (ARA) administration.

methodsThis retrospective study included patients who received ARA to prevent fragility fractures due to GIOP. The cumulative incidence of MRONJ in patients with GIOP was calculated using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to analyze risk factors for MRONJ occurrence.

resultsThe study included 327 individuals. Six patients developed MRONJ; the crude incidence of MRONJ was 1.8%, and the cumulative incidence at 1, 2, 3, 4, and 5 years was 0.32%, 0.97%, 1.35%, 1.85%, and 2.56%, respectively. In this study, 159 teeth were extracted during dental intervention before ARA administration in 58 patients; however, no MRONJ development was observed at the extraction site. Tooth extraction, diabetes mellitus, and duration of ARA administration were not identified as risk factors in this study.

conclusionsThe incidence of MRONJ in patients with GIOP was higher than the previously reported incidence in patients with age-related osteoporosis but lower than the incidence in patients using high-dose ARA. The results support the effectiveness of prophylactic procedures to remove the infected lesions as much as possible from the jawbone and periodontal tissue before ARA administration. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsGlucocorticoidsOsteoporosisAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsTooth ExtractionBone Density Conservation AgentsGlucocorticoidsAntiresorptiveGlucocorticoid-induced osteoporosisOral screeningOsteonecrosisTooth extraction

Identifiers

PMID40237920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.