Trial reportDigestive diseases and sciences2025
Efficacy of Home-Based Versus Hospital-Based Disimpaction with Polyethylene Glycol in Pediatric Functional Constipation: A Randomized Control Study.
Trial report in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Impact of Oral- vs. Nasogastric Tube-Administered Osmotic Laxative on Pediatric Patients with Fecal Impaction Complicating Functional Constipation.Digestive diseases and sciences · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsFunctional constipation (FC) is the most common cause of childhood constipation. Children with FC and fecal impaction need to undergo disimpaction. Polyethylene glycol (PEG) is commonly used for disimpaction either in a hospital setting as a continuous lavage or in a home-based setting over 3-6 days. Randomized control trials comparing the two regimens are not available. The study objectives were to compare the efficacy, side effects, cost-effectiveness, and parental satisfaction of home- and hospital-based disimpaction.
methodsConsecutive children attending our hospital (age: 1-18 years) and diagnosed to have FC as per ROME IV and requiring disimpaction were enrolled. Fecal impaction was established clinically (per-abdomen or per-rectal examination) or radiologically (X-ray abdomen- Barr criteria). Stratified block randomization was done. PEG was administered accordingly in a hospital-based or a home-based setting. The side effects, patient acceptability as per the treatment satisfaction questionnaire for medications (TSQM) and cost incurred were noted.
resultsOne hundred and fifteen children (hospital-based [n = 58], home-based [n = 57]) were enrolled. Successful disimpaction in hospital- and home-based disimpaction arm was 100% and 94.7%, respectively (p = 0.12). Vomiting (27.6% vs 5.3%, p = 0.001) and abdominal distension (31% vs 3.5%, p < 0.001) were higher in patients undergoing hospital-based disimpaction. Cost of treatment was higher in hospital-based disimpaction arm (INR 6,250 [2,228-15,585] vs INR 3,355 [850-18,350], p = < 0.001). Parental satisfaction was greater in home-based disimpaction.
conclusionsHome-based disimpaction using PEG is as effective as hospital-based disimpaction. Disimpaction in a friendlier home environment, at a lower cost and with fewer side effects makes home-based disimpaction preferable in children.
Indexed as
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Registered trials
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