Evidence map›Paper›PMID 40237891›Full record

ArticleVeterinary research communications2025

Age- and agro-climatic zone-specific variations in post-vaccinal antibody responses to FMD vaccination in bovine populations: a longitudinal study from Karnataka, India.

Jagadish B Hiremath, Rohini Bhat, G B Bhavana, Sagar Awati, Shanthkumar B Mannapur, Manjunatha Reddy Gundallahalli, Sharanagouda S Patil, Satheesha S P, Divakar Hemadri, Suresh K P and 3 more

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In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jagadish B HiremathICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India. jagsvet@gmail.com.ORCID http://orcid.org/0000-0002-6606-3771
Rohini BhatICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
G B BhavanaICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Sagar AwatiICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Shanthkumar B MannapurICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Manjunatha Reddy GundallahalliICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Sharanagouda S PatilICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Satheesha S PKarnataka Veterinary, Animal and Fisheries Sciences University, Bidar, Karnataka, India.
Divakar HemadriIndian Council of Agricultural Research (ICAR), Krishi Bhavan, New Delhi, India.
Suresh K PICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Yelahanka, Bengaluru, Karnataka, India.
Saravanan SubramaniamICAR-National Institute of Foot and Mouth Disease, Bhubaneshwar, Odisha, India.
Raveendra HegdeKarnataka Veterinary, Animal and Fisheries Sciences University, Bidar, Karnataka, India.
Rahman HIndian Council of Agricultural Research (ICAR), Krishi Bhavan, New Delhi, India.

Funding

Indian Council of Agricultural Research F. No. AS/8/20/2015-ASR-IV (Part-II)
6 · The paper itself

Abstract

This longitudinal study examined variations in post-vaccination antibody response to Foot-and-Mouth Disease (FMD) vaccination in bovines across different age groups and agro-climatic zones in Karnataka, India. A total of 374 serum samples were collected from 28 villages across nine agroclimatic zones, targeting pre- and post-vaccination titers for FMD virus serotypes O, A, and Asia-1. Analysis via single-dilution liquid-phase blocking ELISA revealed significant findings: pre-vaccination immune proportions were below the herd immunity threshold (< 80%) for serotypes O and Asia-1 but exceeded it for serotype A. Younger bovines (< 24 months) displayed notably lower antibody titers (log₁₀1.67-1.99) compared to older cattle (> 24 months; log₁₀2.14-2.44), highlighting the age-dependent vaccine response variability. Agroclimatic disparities were evident, with regions like the Coastal and Central Dry Zones failing to achieve protective titers (log₁₀<1.8) even post-vaccination, whereas zones like the Eastern Dry Zone demonstrated marked improvements. Post-vaccination seromonitoring showed an overall increase in immune proportions for all serotypes, yet younger cattle and certain agroclimatic zones remained suboptimal. These findings emphasize the importance of region-specific vaccination strategies and the need for tailored booster protocols to enhance immunity in younger bovines. The study underscores the utility of seromonitoring in optimizing FMD control programs by addressing age and agro-climatic disparities in immune responses.

Indexed as

Antibodies, ViralCattle DiseasesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusVaccinationViral VaccinesAge FactorsAnimalsCattleClimateIndiaLongitudinal StudiesAntibodies, ViralViral VaccinesFMDLPB-ELISAPost-vaccinationPre-vaccinationSeromonitoring

Identifiers

PMID40237891

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.