Evidence map›Paper›PMID 40237868›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

Patients on antidepressants are more likely to be discharged to inpatient rehabilitation after lumbar fusion.

Jonathan Dalton, Tristan Fried, Michael Alan McCurdy, Rajkishen Narayanan, Chloe K Herczeg, Yunsoo Lee, Hamd Mahmood, Marco Goldberg, Nikhil Mehta, Antony Fuleihan and 7 more

Abstract read
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In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jonathan DaltonDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.ORCID 0000-0002-7452-2712
Tristan FriedDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Michael Alan McCurdyDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Rajkishen NarayananDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA. rajkishen.narayanan@gmail.com.
Chloe K HerczegDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Yunsoo LeeDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Hamd MahmoodDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Marco GoldbergDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Nikhil MehtaDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Antony FuleihanDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Mark F KurdDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
I David KayeDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Jose A CansecoDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Alan S HilibrandDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Alexander R VaccaroDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Gregory D SchroederDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.
Christopher K KeplerDepartment of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital, 925 Chestnut St, 5th Floor, Philadelphia, PA, 19107, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the association between antidepressant use and inpatient physical therapy performance, as well as discharge disposition after surgery.

methodsPatients undergoing primary 1-3 level lumbar fusion at a single, tertiary care institution from 2017 to 2021 were retrospectively identified. Patient characteristics, surgical details, and surgical outcomes were collected via chart review. Medications were collected based on active medication lists at the patient's preoperative and first postoperative appointment-patients were considered to be taking antidepressants if prescriptions were active at both appointments. Inpatient physical therapy metrics including the distance walked during a single session (session distance) and Activity Measure for Post-Acute Care (AMPAC) scores were collected. Statistical analysis was performed to identify differences between the "antidepressant" and "no antidepressant" groups.

results493 patients (27.7%) were taking antidepressants perioperatively. Patients in the antidepressant group were more likely to be female (p < 0.001), current smokers (p = 0.012), and have a higher Elixhauser comorbidity index (p < 0.001). On regression analysis, the antidepressant group was associated with discharge to inpatient rehabilitation after surgery (p = 0.026). Age (p < 0.001), length of stay (p < 0.001), 1st PT session distance walked (p < 0.001), and improvement in gait distance (p < 0.001) were associated with non-home discharge.

conclusionsAntidepressant use was independently associated with discharge to a rehabilitation facility. These patients were still discharged to these facilities without performing significantly worse in their inpatient physical therapy sessions. These findings suggest that psychosocial factors may play an important role in discharge disposition after spine surgery.

Indexed as

Antidepressive AgentsLumbar VertebraePatient DischargePhysical Therapy ModalitiesSpinal FusionAdultAgedFemaleHumansInpatientsMaleMiddle AgedRetrospective StudiesAntidepressive AgentsAntidepressantsDischarge dispositionLumbar fusionPhysical therapyRehabilitation

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.