Evidence map›Paper›PMID 40237657›Full record

SynthesisAnnals of cardiac anaesthesia2025

Sedation Versus General Anesthesia for Ablation of Ventricular Arrhythmias: A Systematic Review and Meta-Analysis.

Shubh Patel, Jiawen Deng, Areeba Zubair, Kiyan Heybati, Shayan Heybati, Oswin Chang, Umaima Abbas, Umair Tahir, Harikrishnaa B Ramaraju, Chi Y Wong and 6 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of cardiac anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shubh PatelFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jiawen DengFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Areeba ZubairFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Kiyan HeybatiAlix School of Medicine, USA.
Shayan HeybatiFaculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Oswin ChangUBC Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Umaima AbbasSchulich School of Medicine and Dentistry (Windsor), Western University, Windsor, ON, Canada.
Umair TahirFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Harikrishnaa B RamarajuVCU School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
Chi Y WongMichael G. DeGroote School of Medicine (Waterloo Regional Campus), McMaster University, Kitchener, ON, Canada.
Thanansayan DhivagaranSchulich School of Medicine and Dentistry (Windsor), Western University, Windsor, ON, Canada.
Daniel RaynerDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, ON, Canada.
Magnus KreverClinical Research, Sinai Health System, Toronto, ON, Canada.
Tiffany WoelberCardiac Intensive Care Unit, Mayo Clinic, Rochester, MN, USA.
Gurukripa N KowlgiDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Harish RamakrishnaDepartment of Anaesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractVentricular arrhythmias (VA), including ventricular tachycardia and fibrillation, are critical cardiac conditions that are often managed by catheter ablation among those unresponsive to pharmacologic therapy. The choice of anesthesia and sedation regimens for VA ablations may impact arrhythmia inducibility and hemodynamic stability, which can affect procedural success and complication rates. This systematic review and meta-analysis aimed to compare the efficacy and safety of sedation versus general anesthesia (GA) among patients undergoing VA ablation. The review was prospectively registered on PROSPERO (CRD42023441553). Database searches were conducted across five major databases from inception to March 9, 2024 to identify randomized trials or observational studies including adult patients undergoing ablations for VA. Screening and data extraction were completed in duplicate. Risk-of-bias assessments were conducted using ROBINS-I as all included studies were observational, and the quality of evidence was evaluated using the GRADE framework. Six observational studies (N = 16,435) were included. No significant differences were found between sedation and GA for total procedure time (MD: -14.16 minutes; 95%CI: -38.61 to 10.29 minutes), arrhythmia non-inducibility (RR: 0.73; 95% CI: 0.33-1.58), acute ablation success (RR: 1.06; 95% CI: 0.65-1.71), or procedural complications (RR: 0.72; 95% CI: 0.28-1.85). However, sedation was associated with significantly lower intraprocedural hemodynamic instability (RR: 0.28; 95% CI: 0.12-0.70). These findings indicate that while sedation and GA have comparable outcomes, sedation may be associated with less hemodynamic instability during VA ablation. However, more high-quality studies are needed to confirm these results.

Indexed as

Anesthesia, GeneralArrhythmias, CardiacCatheter AblationProcedural SedationTachycardia, VentricularHumansAblationgeneral anesthesiasedationsystematic reviewventricular arrhythmiaventricular tachycardia

Identifiers

PMID40237657
PMCPMC12058075

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.