Evidence map›Paper›PMID 40237568›Full record

ArticleEnvironmental health perspectives2025

The Association between Multiple Environmental Exposures and Symptoms of Generalized Anxiety Disorder in a Prospective, US-Based Cohort Study.

Unnati V Mehta, Grete E Wilt, Charlotte Roscoe, O I Okereke, B A Coull, Peter James, Francine Laden, Hari S Iyer, Jeff D Yanosky, Joel Kaufman and 4 more

Abstract read
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Unnati V MehtaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-0727-4413
Grete E WiltDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Charlotte RoscoeDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
O I OkerekeChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
B A CoullDepartment of Biostatics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Peter JamesDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Francine LadenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Hari S IyerSection of Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Jeff D YanoskyDepartment of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Joel KaufmanDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Melissa R FifferDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Nicole V DeVilleDivision of Population Sciences, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
Isabel HollandDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jaime E HartDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and SusceptibilityR01ES028033 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DOMINICI, FRANCESCA, LADEN, FRANCINE · 2018 to 2022
$3.5M
NCI NIH HHS U01 CA176726NHLBI NIH HHS U01 HL145386NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES028033NIEHS NIH HHS T32 ES007069
6 · The paper itself

Abstract

backgroundEmerging evidence has implicated built and natural environmental exposures in the etiology and exacerbation of anxiety symptoms.

objectivesOur objective was to assess individual and joint associations between neighborhood socioeconomic status (nSES), walkability, greenness, fine particulate matter (

methodsWe included 81,897 participants of the Nurses' Health Study II. GAD symptoms were measured in 2013 and 2017 using the seven-item Generalized Anxiety Disorder scale (GAD-7). Walkability and nSES

resultsIn single-exposure models, summer NDVI (e.g., for DISCUSSION: In this population, higher levels of summer greenness and nSES may be protectively associated with GAD symptoms, whereas medium- and long-term

Indexed as

Air PollutantsAnxiety DisordersEnvironmental ExposureAdultFemaleGeneralized Anxiety DisorderHumansMaleMiddle AgedNeighborhood CharacteristicsNitrogen DioxideParticulate MatterProspective StudiesUnited StatesAir PollutantsNitrogen DioxideParticulate Matter

Identifiers

PMID40237568
PMCPMC12156197

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.