ArticleMicrobiology spectrum2025
Mass cytometry analysis reveals a cross-tissue immune landscape in
Yanyan Tian, Xuan Jiang, Chuntong Bao, Tamin Abdelaal, Dexi Chen, Wenjing Wang, Fengyang Li, Liancheng Lei, Na Li
Abstract read
In one paragraphArticle in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Yanyan Tian *Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.
Xuan Jiang *Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.
Chuntong BaoKey Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.
Tamin AbdelaalLeiden Computational Biology Center, Leiden University Medical Center, Leiden, Netherlands.
Dexi ChenBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, Beijing, China.
Wenjing WangBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, Beijing, China.
Fengyang LiKey Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0000-0001-5102-6284 Liancheng LeiKey Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0000-0002-5872-1842 Na LiKey Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, China.ORCID 0009-0006-9447-6908 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Porcine contagious pleuropneumonia caused by IMPORTANCE: This study explored the cross-tissue immune dynamic landscape in the APP-induced pneumonia model by utilizing high-dimensional mass cytometry. We discovered that APP-induced immune responses are tissue-specific. Key infection-specific clusters in the spleen and peripheral blood were identified, some of which were previously unrecognized. Meanwhile, the specific functions of APP infection-related immune subsets were explored. The research systematically outlined an overview of immune responses in these tissues, deepening the understanding of APP pathogenesis and laying the foundation for the search for diagnostic and therapeutic targets.
Indexed as
Actinobacillus InfectionsActinobacillus pleuropneumoniaePneumoniaAnimalsCytokinesDisease Models, AnimalFemaleFlow CytometryInterleukin-10MiceSpleenSwineCytokinesInterleukin-10Actinobacillus pleuropneumoniaeimmune cell clustersimmune responsemass cytometry
Identifiers
PMID40237529
PMCPMC12131827
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