Evidence map›Paper›PMID 40237466›Full record

ArticlemBio2025

Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast.

Beate Schwer, Isabel Prucker, Ana M Sanchez, Jill Babor, Henning J Jessen, Stewart Shuman

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. EstablishingAnalytical chemistry · 2025
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beate SchwerDepartment of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.ORCID 0000-0002-3824-9819
Isabel PruckerInstitute of Organic Chemistry, University of Freiburg, Freiburg, Baden-Württemberg, Germany.
Ana M SanchezMolecular Biology Program, Sloan Kettering Institute, New York, New York, USA.
Jill BaborMolecular Biology Program, Sloan Kettering Institute, New York, New York, USA.
Henning J JessenInstitute of Organic Chemistry, University of Freiburg, Freiburg, Baden-Württemberg, Germany.
Stewart ShumanMolecular Biology Program, Sloan Kettering Institute, New York, New York, USA.ORCID 0000-0001-5034-6438

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Mechanisms of DNA and RNA TransactionsR35GM126945 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Stewart H Shuman · 2018 to 2026
$8.9M
Inositol pyrophosphate dynamics affect RNA 3'-processing/transcription terminationR01GM134021 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BEATE SCHWER · 2019 to 2026
$2.8M
Deutsche Forschungsgemeinschaft 390939984National Science Foundation 1746057NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM134021NIGMS NIH HHS R01-GM134021NIGMS NIH HHS R35 GM126945NIGMS NIH HHS R35-GM126945
6 · The paper itself

Abstract

Inositol pyrophosphates 5-IP

Indexed as

Acid PhosphataseDiphosphatesInositol PhosphatesPyrophosphatasesSchizosaccharomycesSchizosaccharomyces pombe ProteinsMultifunctional EnzymesPhosphoric Monoester HydrolasesAcid PhosphataseAsp1 protein, S pombeDiphosphatesInositol PhosphatesMultifunctional EnzymesPhosphoric Monoester HydrolasesPyrophosphatasesSchizosaccharomyces pombe Proteinsinositol pyrophosphatespyrophosphatasesSchizosaccharomyces pombe

Identifiers

PMID40237466
PMCPMC12077094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.