Evidence map›Paper›PMID 40237460›Full record

ArticlemBio2025

Peculiar morphology of Asgard archaeal cells close to the prokaryote-eukaryote boundary.

Burak Avcı, Kassiani Panagiotou, Mads Albertsen, Thijs J G Ettema, Andreas Schramm, Kasper Urup Kjeldsen

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. A diverse Palaeoproterozoic microbial ecosystem implies early eukaryogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Burak AvcıSection for Microbiology, Department of Biology, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-2358-7671
Kassiani PanagiotouLaboratory of Microbiology, Wageningen University and Research, Wageningen, Gelderland, The Netherlands.
Mads AlbertsenCenter for Microbial Communities, Aalborg University, Aalborg, Denmark.
Thijs J G EttemaLaboratory of Microbiology, Wageningen University and Research, Wageningen, Gelderland, The Netherlands.
Andreas SchrammSection for Microbiology, Department of Biology, Aarhus University, Aarhus, Denmark.
Kasper Urup KjeldsenSection for Microbiology, Department of Biology, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-7805-5605

Funding

Danmarks Frie Forskningsfond 3103-00299BEuropean Research Council 817834Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.C.192.016Simons Foundation 73592LPIVillum Fonden 36198
6 · The paper itself

Abstract

The emergence of complex eukaryotic cells from prokaryotic ancestors is a major enigma in the history of life. Current data suggest that Asgard archaea are the closest prokaryotic relatives of eukaryotes and have a genetic potential for cellular complexity, suggesting their key role in the evolution of eukaryotes. The Asgard archaeal order Hodarchaeales was recently proposed as the sister lineage of eukaryotes with a unique set of eukaryotic signature proteins. However, there is no microscopic evidence to show the cellular structure of these closest known archaeal relatives of eukaryotes. Here, we retrieved Hodarchaeales-affiliated full-length 16S rRNA sequences from marine sediments (Aarhus Bay, Denmark), representing 0.1% of the relative rRNA read abundance in sequence libraries, and designed new oligonucleotide probes specifically targeting their cells. We then employed catalyzed reporter deposition-fluorescence

Indexed as

ArchaeaEukaryotic CellsProkaryotic CellsDenmarkDNA, ArchaealGeologic SedimentsIn Situ Hybridization, FluorescencePhylogenyRNA, Ribosomal, 16SDNA, ArchaealRNA, Ribosomal, 16SAsgard archaeacellular complexityeukaryogenesisfluorescence microscopyHodarchaealesin situ hybridizationmarine sediments

Identifiers

PMID40237460
PMCPMC12077186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.