Evidence map›Paper›PMID 40237336›Full record

ArticleGut microbes2025

Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode.

Nathalia F Naspolini, Paulo A Schüroff, Pedro A R Vanzele, Davi Pereira-Santos, Tamires Amabili Valim, Kevin S Bonham, André Fujita, Maria Rita Passos-Bueno, Patricia C B Beltrão-Braga, André C P L F Carvalho and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nathalia F NaspoliniInstitute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Paulo A SchüroffSchool of Arts, Sciences and Humanity, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-7808-7818
Pedro A R VanzeleDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-0305-8262
Davi Pereira-SantosDepartment of Applied Mathematics and Statistics, Institute of Mathematics and Computer Sciences, University of Sao Paulo, Sao Carlos, Brazil.ORCID 0000-0002-3766-3137
Tamires Amabili ValimDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-2645-126X
Kevin S BonhamDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0003-3200-7533
André FujitaDivision of Network AI Statistics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-7756-7051
Maria Rita Passos-BuenoDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-9248-3008
Patricia C B Beltrão-BragaInstitute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-0004-1091
André C P L F CarvalhoDepartment of Applied Mathematics and Statistics, Institute of Mathematics and Computer Sciences, University of Sao Paulo, Sao Carlos, Brazil.ORCID 0000-0002-4765-6459
Vanja Klepac-CerajDepartment of Biological Sciences, Wellesley College, Wellesley, MA, USA.ORCID 0000-0001-5387-5706
Guilherme V PolanczykDepartment of Psychiatry, Faculdade de Medicina FMUSP, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-2311-3289
Alline C CamposDepartment of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-4258-3198
Carla R TaddeiInstitute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-0869-0651

Funding

Wellcome Trust
6 · The paper itself

Abstract

Exclusive breastfeeding (EBF) plays a crucial role in infant gut microbiome assembly and development. However, few studies have investigated the effects of EBF in restoring a perturbed microbiome. In this study, we applied whole metagenomic sequencing to assess the gut microbiome assembly in 525 Brazilian infants from 3 to 9 months of age of the Germina Cohort, demonstrating the early determinants of microbial taxonomy and function modulation. Our analysis shows that EBF alters the relative abundance of genes related to the microbiome taxonomy and function, with effects varying by delivery mode. EBF alters the pattern of carbohydrates, lipid metabolism, and cell structure pathways depending on the delivery mode. The microbiome age is closer to chronological infant age in EBF than in non-EBF infants, meaning a lower microbiome maturation index (MMI). Using a complementary machine learning approach, we show that

Indexed as

BacteriaBreast FeedingDelivery, ObstetricGastrointestinal MicrobiomeBrazilCohort StudiesFecesFemaleHumansInfantInfant, NewbornMaleMetagenomicsEarly-life gut microbiomeexclusive breastfeedingmicrobiome functional pathways

Identifiers

PMID40237336
PMCPMC12005435

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.