Evidence map›Paper›PMID 40237227›Full record

SynthesisEuropean journal of neurology2025

Acupuncture Versus Standard Medical Care in the Prophylactic Treatment of Migraine: A Systematic Review and Meta-Analysis.

Francesca Pistoia, Simone Cesarano, Gennaro Saporito, Maria Albanese, Cecilia Lucenti, Secondo Scarsella, Aldo Liguori, Federica Umani Ronchi

Abstract readSystematic ReviewMeta-AnalysisComparative Study
In one paragraph

Synthesis in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca PistoiaDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.ORCID 0000-0003-0790-4240
Simone CesaranoDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.ORCID 0000-0003-4200-837X
Gennaro SaporitoDepartment of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'Aquila, Italy.
Maria AlbaneseNeurology Unit, Regional Referral Headache Center, Tor Vergata University Hospital, Rome, Italy.ORCID 0000-0002-5113-2017
Cecilia LucentiIntegrated Medical Acupuncture, Siena, Italy.
Secondo ScarsellaMaxillofacial Surgery, San Salvatore Hospital, L'Aquila, Italy.
Aldo LiguoriParacelso Institute, Rome, Italy.
Federica Umani RonchiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough innovative pharmacological therapies for migraine prevention are now available, they may not be suitable or effective for all patients due to concerns about tolerability and the varying complexity of the underlying condition. This study systematically reviewed and meta-analyzed acupuncture's effects on migraine prophylaxis compared to standard medical care, focusing on study heterogeneity and issues related to sham interventions.

methodsFollowing the PRISMA guidelines and using the PICO model, the study searched PubMed, Scopus, CNKI, and VIP database from December 1965 to September 2024. Studies evaluating acupuncture's clinical efficacy for migraine prophylaxis, including clinical trials, observational studies, case series, and case reports, were considered. An additional search was conducted on the clinicaltrials.gov database from the beginning of indexing up to September 2024 to include ongoing studies. Quality control and bias assessment were performed. Primary outcomes focused on acupuncture's efficacy and safety versus pharmacological treatments in reducing migraine frequency and intensity. The impact on patients' quality of life was also evaluated.

resultsAt the end of the selection process, 15 studies were eligible. Acupuncture showed no statistically significant difference as a prophylactic treatment for migraine in reducing the frequency of migraine days or pain intensity but did reduce the use of analgesics while improving patients' quality of life.

conclusionCurrent evidence supports acupuncture as an adjunctive therapy in migraine prophylaxis, but challenges such as protocol heterogeneity, dropout biases, the complexities of sham-controlled trials, and the lack of comparison data with newer innovative treatments not yet considered warrant further research.

Indexed as

Acupuncture TherapyMigraine DisordersHumansacupuncturemigraineprophylaxisquality of life

Identifiers

PMID40237227
PMCPMC12000925

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.