ArticlePlastic and reconstructive surgery. Global open2025
Regional Anesthesia and Postoperative Opioid Use in Autologous Breast Reconstruction: A Systematic Review and Meta-analysis.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nerve and fascial plane blocks are common components of early recovery after surgery protocols for autologous breast reconstruction, but there is mixed data regarding their efficacy. This study evaluated the association between regional anesthesia and postoperative opioid use, patient-reported pain, length of stay (LOS), and duration of surgery. Methods: We conducted a systematic review of articles on regional anesthesia in autologous breast reconstruction and a dual extraction of outcomes. Data of interest included total, 24-hour, and 48-hour opioid use (intravenous [IV] morphine milligram equivalents [MMEs]), patient-reported pain, and length of surgery and stay. We performed meta-analyses with random effects models for mean difference (MD). Results: We included 21 studies for analysis. Total opioid use was reduced among patients who received regional anesthesia (MD = -10.28 IV MMEs, ~3 oxycodone 5-mg equivalents, Conclusions: Regional anesthesia was associated with a statistically but not clinically significant reduction in total postoperative opioid use and LOS following autologous breast reconstruction. Total opioid use was not significantly different when considering only randomized controlled trial data.
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