Evidence map›Paper›PMID 40236948›Full record

ArticleFrontiers in neuroscience2025

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function.

Sheila M Fleming, Sophia Scott, Edward J Hamad, Danielle E Herman, John G Holden, Lily Yan, Katrina Linning-Duffy, Christopher J Kemp, Joseph R Patterson, Kathryn M Miller and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sheila M FlemingDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Sophia ScottDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Edward J HamadDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
Danielle E HermanDepartment of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, United States.
John G HoldenDepartment of Psychology, University of Cincinnati, Cincinnati, OH, United States.
Lily YanDepartment of Psychology, Michigan State University, East Lansing, MI, United States.
Katrina Linning-DuffyDepartment of Psychology, Michigan State University, East Lansing, MI, United States.
Christopher J KempDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Joseph R PattersonDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Kathryn M MillerDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Michael KubikDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Nathan KuhnDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Anna C StollDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Megan F DuffyDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Kathy Steece-CollierDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Allyson Cole-StraussDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Jack W LiptonDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Kelvin C LukDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Caryl E SortwellDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.

Funding

ATP13A2 and Susceptibility to NeurodegenerationR01ES031124 · NIEHS · NORTHEAST OHIO MEDICAL UNIVERSITY · PI FLEMING, SHEILA · 2020 to 2024
$1.7M
NIEHS NIH HHS R01 ES031124
6 · The paper itself

Abstract

Introduction: The alpha-synuclein ( Methods: Male Fischer 344 rats were injected unilaterally in the striatum with a total of 24μg Results: At six months post injection, Conclusion: Thus, using the present

Indexed as

bradykinesiacognitive functiondopaminenigrostriatalParkinson’s disease

Identifiers

PMID40236948
PMCPMC11996896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.