Evidence map›Paper›PMID 40236864›Full record

ArticleWorld journal of diabetes2025

Elevated waist-to-hip ratio, as an abdominal obesity index, predicts the risk of diabetic kidney injury.

Di-Ni Lin, Dan Li, Meng-Meng Peng, Hong Yang, Zhen-Zhen Lin, En-Ling Ye, Wen-Ting Chen, Meng-Xue Zhou, Xian-En Huang, Xue-Mian Lu

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Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Di-Ni LinDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Dan LiKey Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Company Limited, Hangzhou 310000, Zhejiang Province, China.
Meng-Meng PengDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Hong YangDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Zhen-Zhen LinDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
En-Ling YeDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Wen-Ting ChenDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Meng-Xue ZhouDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Xian-En HuangDepartment of Endocrinology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.
Xue-Mian LuWenzhou Key Laboratory for the Diagnosis and Prevention of Diabetic Complication, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic nephropathy (DN) is associated with a high incidence of type 2 diabetic mellitus (T2DM) in Asia. Central obesity is an important risk factor for DN, represented by a series of indices, including waist circumference, waist-to-hip ratio (WHR), hip circumference, and visceral to subcutaneous fat area ratio (VSR). However, limited research has focused on the association between these indices and DN.

aimTo elucidate the relationship between central fat distribution, as measured by WHR and VSR, and the DN progression.

methodsBetween August 2018 and April 2023, a total of 991 individuals were retrospectively recruited from the Rui'an People's Hospital for this cross-sectional analysis. The 753 individuals with T2DM were divided into three groups according to the urinary albumin/creatinine ratio (ACR): normal albuminuria (

resultsOur results indicated that WHR and VSR were closely correlated with sex, ageing, body mass index, hypertension, T2DM causes, and experience of drinking and smoking, and potential relationships between these factors and DN progression were observed. WHR, but not VSR, gradually increased with the severity of early-stage renal injury. Abnormal serum lipid levels in T2DM patients with early-stage renal injury were strongly correlated with WHR. Logistic regression analysis revealed that WHR may be an independent risk factor for early-stage renal injury.

conclusionIn patients with T2DM, WHR level, rather than VSR level, is closely associated with early-stage renal injury. An abnormal serum lipid spectrum was common in all stages of renal injury and was strongly related to high WHR. Thus, WHR measurement might be a valuable tool for the early prevention of renal injury, which could guide clinical monitoring and prevent diabetic complications.

Indexed as

Abnormal serum lipidsCentral obesityDiabetic nephropathyType 2 diabetes mellitusWaist-to-hip ratio

Identifiers

PMID40236864
PMCPMC11947918

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