Evidence map›Paper›PMID 40236771›Full record

ArticleiMeta2025

Transmission of antimicrobial resistance genes from the environment to human gut is more pronounced in colorectal cancer patients than in healthy subjects.

Weixin Liu, Harry C H Lau, Xiao Ding, Xiaole Yin, William Ka Kei Wu, Sunny Hei Wong, Joseph J Y Sung, Tong Zhang, Jun Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weixin LiuInstitute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China.
Harry C H LauInstitute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China.
Xiao DingInstitute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China.
Xiaole YinEnvironmental Microbiome Engineering and Biotechnology Laboratory, Center for Environmental Engineering Research, Department of Civil Engineering The University of Hong Kong Hong Kong SAR China.
William Ka Kei WuInstitute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China.
Sunny Hei WongLee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore.
Joseph J Y SungLee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore.
Tong ZhangEnvironmental Microbiome Engineering and Biotechnology Laboratory, Center for Environmental Engineering Research, Department of Civil Engineering The University of Hong Kong Hong Kong SAR China.
Jun YuInstitute of Digestive Disease and The Department of Medicine and Therapeutics State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong Hong Kong SAR China.ORCID 0000-0001-5008-2153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a major global health concern. However, the source of gut resistome remains unsolved. We aimed to analyze the contribution of environmental antimicrobial resistance genes (ARGs) to colorectal cancer (CRC) patients. Here, we collected metagenomic data from 1,605 human stool samples (CRC = 748; healthy = 857) and 1,035 city-matched environmental samples, in which 110 CRC, 112 healthy, and 56 environmental samples were newly collected. Compared to healthy subjects, CRC patients had significantly higher ARG burden (

Indexed as

antimicrobial resistance genecolorectal cancerenvironmenthorizontal gene transfer

Identifiers

PMID40236771
PMCPMC11995172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.