Evidence map›Paper›PMID 40236705›Full record

ArticleFrontiers in immunology2025

Two chemotherapeutic agents expand stem-like CD62L

Xiaokang Ruan, Linwei Wu, Zijian Tang, Yao Li, Jin Wang, Haolin Jiang, Li Zhang, Shengjia Wang, Zhaoqiang Chen, Chenlei Yuan and 4 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. 5-FU chemotherapy induces functional CD7Science China. Life sciences · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaokang Ruan *Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Linwei Wu *Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zijian Tang *The Affiliated Infectious Diseases Hospital, Suzhou Medical College of Soochow University, Suzhou, China.
Yao LiDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jin WangDepartment of General Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Haolin JiangDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Li ZhangDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Shengjia WangDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Zhaoqiang ChenDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Chenlei YuanDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yujian XiaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yan PanDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Jianling GaoDepartment of Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Xin ZhaoDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Recent findings reveal that the precursors of exhausted CD8 Methods: Tpex cell-associated subpopulations in human colorectal tumors were analyzed by using single-cell sequencing data. CT26 and B16 tumor models of wild type and Eomes conditional knockout mice were constructed, and the changes of T Results: In this study, we demonstrated that DAC and 5-FU expanded CD8 Conclusion: The present study demonstrated that both DAC and 5-FU promoted the differentiation of stem-like CD8

Indexed as

Antimetabolites, AntineoplasticCD8-Positive T-LymphocytesColorectal NeoplasmsDecitabineFluorouracilL-SelectinLymphocytes, Tumor-InfiltratingMelanoma, ExperimentalAnimalsAntibiotics, AntineoplasticCell Line, TumorCross-PrimingDoxorubicinGene Knockout TechniquesHumansLymph NodesAntibiotics, AntineoplasticAntimetabolites, AntineoplasticDecitabineDoxorubicinEOMES protein, humanFluorouracilL-SelectinSELL protein, humanT-Box Domain Proteinsantitumor immune responsesCD62L+ CD8+ Tpex cellsCD8+ TTSM cellschemotherapeutic agentsEomes

Identifiers

PMID40236705
PMCPMC11996895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.