Evidence map›Paper›PMID 40236667›Full record

ArticleEncyclopedia2024

Interleukin-33 and Obesity-Related Inflammation and Cancer.

Cameron Kowitt, Qiuyang Zhang

Abstract read
In one paragraph

Article in Encyclopedia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cameron KowittDepartment of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Qiuyang ZhangDepartment of Structural & Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0001-7346-5296

Funding

The role of the CMV-associated reactive oxygen species in age-relatedP20GM103629 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI TIAN, AIGUO · 2012 to 2021
$22.4M
The Impact of Aging on Prostate Cancer with Age-Related Disruption of Th17/Treg AxisR01CA255802 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI ZHANG, QIUYANG · 2021 to 2025
$1.7M
NCI NIH HHS R01 CA255802NIGMS NIH HHS P20 GM103629
6 · The paper itself

Abstract

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family. It is primarily associated with type 2 immune responses. It interacts with a receptor complex on immune cells in reaction to tissue damage or cellular injury. IL-33 is crucial in immune responses and is involved in various autoimmune and inflammatory diseases. Obesity is marked by chronic inflammation and is a known risk factor for several types of cancer. Recent studies have shown that IL-33 and its receptor complex are expressed in adipose (fat) tissue, suggesting they may play a role in obesity. While inflammation connects obesity and cancer, it is not yet clear whether IL-33 contributes to cancer associated with obesity. Depending on the cellular context, inflammatory environment, expression levels, and bioactivity, IL-33 can exhibit both protumorigenic and antitumorigenic effects. This review will explore the various functions of IL-33 in the inflammation linked to obesity and its relationship with cancer.

Indexed as

cancerIL-33immune responseinflammationobesityST2

Identifiers

PMID40236667
PMCPMC11999627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.