Evidence map›Paper›PMID 40236650›Full record

ArticleFrontiers in oncology2025

Case Report: Medullary carcinoma of the pancreas with

Koushiro Ohtsubo, Shigeki Sato, Hiroyuki Sakaguchi, Hiroshi Kotani, Akihiro Nishiyama, Kaname Yamashita, Seiji Yano, Fumihito Toshima, Dai Inoue, Toshifumi Gabata and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. MLH1 promoter methylation in pancreatic ductal adenocarcinoma: frequent but not prognostic.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Koushiro OhtsuboDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Shigeki SatoDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Hiroyuki SakaguchiDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Hiroshi KotaniDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Akihiro NishiyamaDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Kaname YamashitaDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.
Seiji YanoDepartment of Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Japan.
Fumihito ToshimaDepartment of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
Dai InoueDepartment of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
Toshifumi GabataDepartment of Radiology, Kanazawa University Hospital, Kanazawa, Japan.
Hiroko IkedaDivision of Human Pathology, Kanazawa University Hospital, Kanazawa, Japan.
Atsushi WatanabeDivision of Clinical Genetics, Kanazawa University Hospital, Kanazawa, Japan.
Kenji NotoharaDepartment of Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Japan.
Takao FujisawaDepartment of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Yoshiaki NakamuraInternational Research Promotion Office, National Cancer Center Hospital East, Kashiwa, Japan.
Takayuki YoshinoInternational Research Promotion Office, National Cancer Center Hospital East, Kashiwa, Japan.
Kunio MiyakeDepartment of Epidemiology and Environmental Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan.
Kazuhiro MiwaInternal Medicine, Komatsu Municipal Hospital, Komatsu, Japan.
Shinji TakeuchiDepartment of Medical Oncology, Kanazawa University Hospital, Kanazawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a 75-year-old woman with a pancreatic body mass. Pathological findings from endoscopic ultrasonography-guided fine-needle aspiration revealed medullary carcinoma of the pancreas (MCP). Deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H) were identified through immunohistochemistry and next generation sequencing, respectively. While immunohistochemistry suggested MLH1 abnormality, no

Indexed as

deficient mismatch repairimmune checkpoint inhibitormedullary carcinoma of the pancreasmicrosatellite instabilityMLH1 hypermethylationpembrolizumab

Identifiers

PMID40236650
PMCPMC11997870

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.