ArticleFrontiers in oncology2025
Survival outcomes and prognostic factors in surgically treated adult pilocytic astrocytomas.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Adult pilocytic astrocytomas: challenging the benign paradigm with surgical risks, recurrence dynamics, and molecular insights.Neurosurgical review · 2025Article
- Unusual localization of pilocytic astrocytoma at the foramen of Monro mimicking a colloid cyst: a case report and literature review.Frontiers in oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Pilocytic astrocytomas (PA) in adult patients are rare and the efficacy of postoperative adjuvant treatments remains unclear. This study aims to investigate the survival outcome and prognostic factors in surgically treated adult PA. Methods: A total of 90 consecutive adult patients with newly diagnosed PA were enrolled. Among the patients, 47 (52%) were male, with a median age of 28 years (18-70 years). Preoperative neurological deficits were observed in 43 (48%) patients. The most common tumor locations were cerebellar and cerebral hemispheres (28% and 27%, respectively), while 23% of tumors were located in deeper brain structures. The median follow-up duration was 88months (12-304 months). Results: Gross total removal (GTR) was achieved in 55 (61%) patients. At the final follow-up, 12 (13%) patients had died, and 23 (26%) experienced disease progression. The 1, 2, and 5-year overall survival (OS) rates were 93%, 91%, and 87%, respectively, while the progression-free survival (PFS) rates were 88%, 80%, and 77%, respectively. The recurrence rate in patients who underwent GTR was 11%, compared with 53% and 45% in those without GTR, with or without adjuvant treatments, respectively. The tumors in the deeper brain locations had significantly lower GTR rates (14%) compared with other locations (75%; Conclusion: Adult PA exhibited more aggressive behavior compared with pediatric PA. These aggressive behaviors including preoperative neurological deficits, deeper tumor location, and lower GTR rates were significantly associated with poor prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.