Evidence map›Paper›PMID 40236539›Full record

ArticleACS medicinal chemistry letters2025

Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the

Yildiz Tasdan, Gautham R Balaji, Naureen Akhtar, Olga Ilyichova, Taylor Cunliffe, Begoña Heras, Loic Le Strat, James Murray, Ben Capuano, Martin J Scanlon and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yildiz TasdanDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.ORCID https://orcid.org/0000-0002-6507-7223
Gautham R BalajiDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.
Naureen AkhtarDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.
Olga IlyichovaDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.
Taylor CunliffeDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Kingsbury Drive, Bundoora 3083, Australia.
Begoña HerasDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Kingsbury Drive, Bundoora 3083, Australia.
Loic Le StratVernalis (R&D) Ltd., Granta Park, Great Abington CB21 6GB, Cambridge, U.K.
James MurrayVernalis (R&D) Ltd., Granta Park, Great Abington CB21 6GB, Cambridge, U.K.ORCID https://orcid.org/0000-0003-1007-8218
Ben CapuanoDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.ORCID https://orcid.org/0000-0001-5434-0180
Martin J ScanlonDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.ORCID https://orcid.org/0000-0002-9230-7506
Bradley C DoakDepartment of Medicinal Chemistry, Monash University, 381 Royal Parade, Parkville 3052, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small molecules that covalently modify proteins typically contain an electrophile that selectively reacts with nucleophilic residues in a protein target, such as cysteine, serine, and threonine. Targeting other amino acids is an emerging strategy in covalent probe design. This study reports the discovery and characterization of the covalent reaction between a novel allene warhead and a histidine residue in the active site of the bacterial thiol-disulfide oxidoreductase enzyme

Identifiers

PMID40236539
PMCPMC11995234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.