Evidence map›Paper›PMID 40236511›Full record

ArticleClinical kidney journal2025

The prevalence of immunoglobulin A nephropathy in the European Union and the impact of the COVID-19 pandemic: an estimation approach utilizing the kidney biopsy frequency.

Jocelyn Buisker, Sigrid Behr, Nadine Janet Kubesch, Moise E Turkson, Bart Maes, Dmitrij Kollins, Nicholas J A Webb, Jürgen Floege

Abstract read
In one paragraph

Article in Clinical kidney journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jocelyn BuiskerQuantitative Safety and Epidemiology, Novartis Pharma AG, Basel, Switzerland.
Sigrid BehrQuantitative Safety and Epidemiology, Novartis Pharma AG, Basel, Switzerland.
Nadine Janet KubeschLife Science-Intuitive Operation and Automation, Cognizant Technology Solutions, Barcelona, Spain.
Moise E TurksonLife Science-Intuitive Operation and Automation, Cognizant Technology Solutions, London, UK.
Bart MaesDepartment of Nephrology, AZ Delta, Roeselare, Belgium.
Dmitrij KollinsClinical Development, Novartis Pharma AG, Basel, Switzerland.
Nicholas J A WebbClinical Development, Novartis Pharma AG, Basel, Switzerland.
Jürgen FloegeDivision of Nephrology and Rheumatology, RWTH Aachen University Hospital, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Immunoglobulin A nephropathy (IgAN) is the most common type of primary glomerulonephritis, requiring a kidney biopsy for diagnosis. This study aimed to estimate the prevalence of primary IgAN within the European Union (EU) and investigate the potential impact of the coronavirus disease 2019 (COVID-19) pandemic on kidney biopsy rates and IgAN diagnosis frequency. Methods: We conducted four comprehensive literature searches to identify data on the IgAN prevalence and incidence, native kidney biopsy rates and COVID-19 impact on these metrics. We calculated country-specific prevalence estimates based on a combination of published and modeled data, incorporating biopsy frequency and the Healthcare Access and Quality Index (HAQI). The EU IgAN prevalence was derived from country-specific prevalence estimates weighted by population size. Results: The estimated prevalence of IgAN in the EU was 4.31 per 10 000 population, with large geographic variation among countries, ranging from 0.16 to 14.4 per 10 000 population. A strong correlation was observed between the IgAN incidence and biopsy rate (R Conclusion: Our findings confirm the rarity of IgAN, albeit the most common type of glomerulonephritis. They underscore a robust correlation between biopsy rates and IgAN incidence, influenced by healthcare access and quality. The COVID-19 pandemic's temporary suppression of biopsy rates in 2020 suggests potential delays in IgAN diagnosis, warranting further investigation into the long-term effects.

Indexed as

epidemiologyglomerulonephritisIgA nephropathykidney biopsysystematic review

Identifiers

PMID40236511
PMCPMC11997654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.