ArticleAmerican journal of ophthalmology case reports2025
Evaluation of blood flow in arteritic anterior ischemic optic neuropathy using laser speckle flowgraphy: A case series.
Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Identification of risk factors for relapse at initial onset in myelin oligodendrocyte glycoprotein antibody-associated optic neuritis using ophthalmic findings.Japanese journal of ophthalmology · 2026Article
- Detection of early ocular circulatory changes in Takayasu arteritis using laser speckle flowgraphy.American journal of ophthalmology case reports · 2026Article
- Differentiation of acute-phase AQP4-IgG+ optic neuritis from CNS inflammatory diseases using optic nerve head blood flow analysis.Scientific reports · 2025Article
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8 authors.
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Abstract
Background: Arteritic anterior ischemic optic neuropathy (AAION), primarily caused by giant cell arteritis, is a leading cause of blindness. This disease results in significant ocular blood flow (BF) impairment, though data on ocular hemodynamics are limited. Methods: This observational case series enrolled four patients treated for AAION (age: 81.8 ± 7.8 years; male to female ratio: 3:1) who underwent laser speckle flowgraphy (LSFG) scanning at the initial visit and after steroid treatment in both eyes. Mean blur rate (MBR), an LSFG parameter that represents BF velocity, was obtained in the optic nerve head vessel area (ONH-MV), ONH tissue area (ONH-MT), and peripapillary choroid, in addition to common ophthalmologic parameters. Results: At the initial visit, all affected eyes had no light perception in best-corrected visual acuity (BCVA) testing, and three cases had a severe increase in circumpapillary retinal nerve fiber layer thickness (cpRNFLT; 191.00 ± 42.03 μm). Pre-treatment, all affected eyes showed decreases in ONH-MV, ONH-MT, and choroidal MBR; this improved after steroid treatment by 80.3 ± 107.6 %, 39.1 ± 79.7 %, and 289.4 ± 303.4 %, respectively. Pre-treatment, all fellow eyes showed no impairment in BCVA or changes in the cpRNFLT. Post-treatment, two fellow eyes showed an increase in ONH-MV and ONH-MT parameters (72.8 ± 32.6 % and 82.2 ± 22.3 %, respectively), while all fellow eyes showed an increase in choroidal MBR (152.7 ± 126.1 %). Conclusion: LSFG could be useful for monitoring ocular BF changes in eyes with AAION and asymptomatic fellow eyes before and after steroid treatment.
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