Evidence map›Paper›PMID 40236498›Full record

ArticleMolecular therapy. Methods & clinical development2025

Virally mediated enhancement of efferent inhibition reduces acoustic trauma in wild-type murine cochleas.

Eleftheria Slika, Paul A Fuchs, Megan Beers Wood

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss.International journal of molecular sciences · 2026
    Review
  2. Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Advancing precision ear medicine: leveraging animal models for disease insights and therapeutic innovations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Eleftheria SlikaDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Paul A FuchsDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Megan Beers WoodDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

THE CHOLINERGIC RESPONSE OF COCHLEAR HAIR CELLSR01DC001508 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Amanda M. Lauer · 1992 to 2026
$13.2M
Type II Afferents and Cochlear DamageR01DC016559 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI ELISABETH GLOWATZKI · 2017 to 2026
$4.9M
NIDCD NIH HHS R01 DC001508NIDCD NIH HHS R01 DC016559
6 · The paper itself

Abstract

Noise-induced hearing loss (NIHL) poses an emerging global health problem with only ear protection or sound avoidance as preventive strategies. The cochlea receives some protection from medial olivocochlear efferent neurons, providing a potential target for therapeutic enhancement. Cholinergic efferents release acetylcholine (ACh) to hyperpolarize and shunt the outer hair cells (OHCs), reducing sound-evoked activation. The (α9)

Indexed as

adeno-associated viruscholinergic inhibitioncochlear efferentsgene therapynicotinic receptornoise-induced hearing lossolivocochlear systemouter hair cellposterior semicircular canal injection

Identifiers

PMID40236498
PMCPMC11999434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.