ArticlemedRxiv : the preprint server for health sciences2025
Associations Between Plasma Omega-3, Fish Oil Use and Risk of AF in the UK Biobank.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To determine the relationship between plasma omega-3 levels and incident atrial fibrillation (AF), and the association between fish oil supplement (FOS) use and risk for AF. Methods and Analysis: Recent studies in UK Biobank concluded that FOS use was associated with increased risk of incident AF. Conversely, a meta-analysis found inverse relationships between blood levels of omega-3 and AF risk. We performed a prospective observational study linking plasma omega-3 levels and reported FOS use with AF risk in UK Biobank. Among UK Biobank participants without prevalent AF, 261 108 had plasma omega-3 levels and 466 169 reported FOS use. The primary outcome was incident AF during follow-up (median 12.7 years). Multivariable-adjusted hazard ratios (HR, 95% confidence intervals, CI) for fatty acids were computed continuously (per inter-quintile range, IQ Results: Plasma omega-3 levels were inversely associated with incident AF (HR per IQ Conclusion: Higher circulating omega-3 levels were linked to reduced AF risk in UK Biobank. Further, after age was adjusted for as a continuous variable, no association was found between fish oil supplement use and AF.
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