Evidence map›Paper›PMID 40236433›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.

Mark Sanderson-Cimino, Alden L Gross, Leslie S Gaynor, Emily W Paolillo, Rowan Saloner, Marilyn S Albert, fLiana G Apostolova, Brooke Boersema, Adam L Boxer, Bradley F Boeve and 31 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Mark Sanderson-CiminoMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-5872-3186
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Leslie S GaynorDivision of Geriatric Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Emily W PaolilloMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Rowan SalonerMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-1351-6183
Marilyn S AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
fLiana G ApostolovaDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Brooke BoersemaDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.
Adam L BoxerMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN, 55905, USA.ORCID 0000-0002-4153-8187
Kaitlin B CasalettoMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Savannah R HallgarthMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Valentina E DiazMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Lindsay R ClarkWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53726, USA.
Pauline MaillardDepartment of Neurology, University of California at Davis, Sacramento, CA, 95816, USA.ORCID 0000-0003-3516-6345
Ani EloyanDepartment of Biostatistics, Center for Statistical Sciences, Brown University, Providence, RI, 02912, USA.
Sarah Tomaszewski FariasDepartment of Neurology, University of California at Davis, Sacramento, CA, 95816, USA.
Mitzi M GonzalesDepartment of Neurology, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA.
Dustin B HammersDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Renaud La JoieMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0003-2581-8100
Yann CobigoMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-0354-4092
Amy WolfMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Benjamin M HampsteadDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA.
Dawn Mechanic-HamiltonDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bruce L MillerMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Gil D RabinoviciMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
John M RingmanDepartment of Neurology, Keck School of Medicine at USC, Los Angeles, CA, 90033, USA.
Howie J RosenMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Sephira G RymanCenter for Memory & Aging, University of New Mexico, Albuquerque, NM, 87110, USA.ORCID 0000-0002-1758-3391
Jillian L PrestopnikCenter for Memory & Aging, University of New Mexico, Albuquerque, NM, 87110, USA.
David P SalmonDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, 92161, USA.
Glenn E Smith1Florida Alzheimer's Disease Research Center, Gainesville, FL, 32610, USA.
Charles DeCarliDepartment of Neurology, University of California at Davis, Sacramento, CA, 95816, USA.
Kumar B RajanRush Institute for Healthy Aging, Rush University Medical Center, Chicago, IL, 60612, USA.
Lee-Way JinDepartment of Pathology and Laboratory Medicine University of California, Davis, CA, 95817, USA.
Jason HinmanDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, 90095, United States.
David K JohnsonDepartment of Neurology, University of California at Davis, Sacramento, CA, 95816, USA.ORCID 0000-0003-3670-8054
Danielle HarveyDepartment of Public Health Sciences University of California, Davis, CA, 95616, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.ORCID 0000-0003-0677-8158
Joel H KramerMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.
Adam M StaffaroniMemory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-3903-9805

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Adam Mark Staffaroni · 2019 to 2026
$120.9M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
The Clinical Significance of Incidental White Matter Lesions on MRI Amongst a Diverse Population with Cognitive Complaints (INDEED)U19NS120384 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Kumar B. Rajan · 2020 to 2026
$61.9M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
Early Onset Alzheimer's Disease ConsortiumR56AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2017 to 2017
$7.7M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)R35AG072262 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAMPSTEAD, BENJAMIN MICHAEL · 2021 to 2025
$4.2M
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseU01NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2023 to 2025
$3.2M
NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066530NIA NIH HHS R35 AG072262NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG057195NIA NIH HHS U19 AG063911NINDS NIH HHS U01 NS100608NINDS NIH HHS U19 NS120384NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

introductionList-learning tasks are important for characterizing memory in ADRD research, but the Uniform Data Set neuropsychological battery (UDS-NB) lacks a list-learning paradigm; thus, sites administer a range of tests. We developed a harmonized memory composite that incorporates UDS memory tests and multiple list-learning tasks.

methodsItem-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogenous sample (n=5943) who completed the UDS-NB and one of five list-learning tasks. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, and plasma phosphorylated tau (p-tau181 and p-tau217). Test-retest reliability was assessed. Analyses were replicated in a racially/ethnically diverse cohort (n=1058).

resultsFit indices, loadings, distributions, and test-retest reliability were adequate. Expected associations with demographics and clinical measures within development and validation cohorts supported validity. DISCUSSION: This composite enables researchers to incorporate multiple list-learning tasks with other UDS measures to create a single metric.

Indexed as

Alzheimer’s Dementia and Related DisordersCo-calibrationCognitionHarmonizationMemoryNeurodegenerationNeuropsychology

Identifiers

PMID40236433
PMCPMC11998833

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.