Evidence map›Paper›PMID 40236304›Full record

ArticleClinical case reports2025

Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature.

Iva Skocilic, Alojzije Kosic, Ivona Badovinac, Tajana Filipec Kanizaj, Renata Dobrila Dintinjana, Maja Kolak, Anamarija Bukovica, Sanja Ropac, Ivana Mikolasevic

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iva SkocilicClinical Hospital Center Rijeka Rijeka Croatia.
Alojzije KosicClinical Hospital Center Rijeka Rijeka Croatia.
Ivona BadovinacClinical Hospital Center Rijeka Rijeka Croatia.
Tajana Filipec KanizajMerkur Clinical Hospital Zagreb Croatia.
Renata Dobrila DintinjanaClinical Hospital Center Rijeka Rijeka Croatia.
Maja KolakClinical Hospital Center Rijeka Rijeka Croatia.
Anamarija BukovicaClinical Hospital Center Rijeka Rijeka Croatia.
Sanja RopacClinical Hospital Center Rijeka Rijeka Croatia.
Ivana MikolasevicClinical Hospital Center Rijeka Rijeka Croatia.ORCID https://orcid.org/0000-0001-9676-0642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As immunotherapy is becoming more inevitable in everyday oncology, we are witnessing a higher number of patients who are on immunosuppressive medication but are also candidates for immune checkpoint inhibitors (ICIs) treatment. There have been few case reports and several small retrospective studies investigating the use of ICIs in liver transplant recipients mainly with hepatocellular carcinoma and skin cancer, but there is no report regarding the use of atezolizumab for the treatment of metastatic breast cancer in liver transplant recipients. We are presenting a metastatic breast cancer female patient undergoing both immunosuppressive treatment after liver transplantation due to cryptogenic liver failure and anti-programmed death ligand 1 (PDL1) medication-atezolizumab whose liver enzymes and tacrolimus level we have monitored intensively through 18 months and is still ongoing. Our patient has not presented with any signs of acute graft rejection and has a regression on follow-up imaging despite the treatment combination.

Indexed as

atezolizumabbreast cancerimmune checkpoint inhibitorsliver transplantationmalignancy

Identifiers

PMID40236304
PMCPMC11997367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.