ReviewBiochemistry and biophysics reports2025
Ion channel mutations and cancer.
Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Bdelloid rotifers harbor a voltage-gated proton channel with distinct mechanistic features.Nature communications · 2026Article
- Review
- Hydrogel-Based Delivery of Ion Channel Modulators for Cancer Therapy: Current Advances and Future Perspectives.Gels (Basel, Switzerland) · 2026Review
- Hydroquinidine Modulates Histopathological, Inflammatory, Apoptotic, EMT-Related, and PI3K/AKT/mTOR-Associated Markers in a DMH-Induced Rat Model of Colon Cancer.International journal of molecular sciences · 2026Article
- DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuatesJournal of virology · 2026Article
- Single-cell RNA sequencing data analysis reveals differential expressions of ion channels in immunity response to pulmonary COVID-19 infection.Biochemical and biophysical research communications · 2026Article
- Hv1 channel in immune cells and pharmacology.Pharmacological research · 2025Review
- A novel gain-of-function mutationAmerican journal of cardiovascular disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Cancer is characterized by uncontrolled growth and spread of abnormal cells, driven by genetic, environmental, and lifestyle factors. Genetic mutations contribute to hallmark processes of cancer progression such as sustained proliferation, apoptosis resistance, and immune evasion. Ion channels are pore-forming transmembrane proteins that regulate ion transport across cellular membranes, influencing various cellular functions. Recent studies have indicated the emerging roles of ion channel proteins in cancer. Ion channels are critical for cellular processes like proliferation, apoptosis, migration, and angiogenesis, and dysregulation of ion channels by genetic mutations disrupts these processes, enabling tumor growth, invasion, and metastasis. Ion channel gene mutations have been associated with various cancer subtypes. These ion channel mutations either dysregulate ion channel activity associated with intracellular signaling pathways in cell survival and division, or influence the tumor microenvironment by modifying pH, oxygenation, or ion concentrations, which might facilitate tumor growth and gene expression and contribute to oncogenesis. In the present review, we discuss ion channel regulation of cancer biology and summarize recent studies in ion channel mutations associated with cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.