Evidence map›Paper›PMID 40236295›Full record

ArticleBiochemistry and biophysics reports2025

Effects of sevoflurane and isoflurane on acute myocardial infarction model establishment in mice.

Jia-Nan Li, Liu-Hao-Nan Zeng, Lu Jin, Ji-Tong Liu

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In one paragraph

Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Jia-Nan LiDepartment of Anesthesiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan Province, China.
Liu-Hao-Nan ZengDepartment of Anesthesiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan Province, China.
Lu JinDepartment of Anesthesiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan Province, China.
Ji-Tong LiuDepartment of Anesthesiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The selection of anesthetic drugs in the preparation of an acute myocardial infarction (AMI) model is very important. We specifically focus on various effects of sevoflurane and isoflurane in a murine AMI model, which have not been previously compared. Furthermore, we evaluated success of our AMI model using following methods: echocardiography, TTC staining, and PCR testing. The results show that compared to the isoflurane group, the sevoflurane group mice had shorter anesthetic induction(66.40 ± 2.90S vs. 125.10 ± 6.30S P < 0.0001) and recovery times(28.00 ± 1.07S vs. 56.88 ± 4.14S, P < 0.0001), lower incidence of respiratory depression (0 % vs. 50.00 %, P = 0.0325), and more successful models (93.33 % vs. 60.00 %, P = 0.0801). There were no significant differences in cardiac function, infarction area(49.41 ± 4.18 % vs. 48.66 ± 3.79 %, P = 0.5266), or inflammatory factors in the myocardial infarction area between the two groups. Sevoflurane may therefore be a better choice for the establishment of AMI models in mice.

Indexed as

Acute myocardial infarctionAnimal modelInhalation anestheticsMice

Identifiers

PMID40236295
PMCPMC11999574

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