SynthesisFrontiers in cardiovascular medicine2025
Clinical significance of NT-proBNP as a predictive biomarker of depressive symptoms in cardiac patients.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Impacts of Sacubitril-Valsartan versus Valsartan on Left Ventricular Remodeling and Cardiac Function in Patients with Ischemic Heart Failure and Reduced Ejection Fraction: A Randomized Double-blinded Controlled Trial.Cardiovascular & hematological disorders drug targets · 2026Trial
- Distinct Biomarker Patterns Reveal Metabolic-Inflammatory Profiles Across Mental Disorders.Biomolecules · 2026Article
- Multimodal AI-driven object detection with uncertainty quantification for cardiovascular risk assessment in autistic patients.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
7 authors.
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Abstract
Introduction: Depression is a significant comorbidity linked to poor subjective and objective health outcomes in cardiac patients. The paucity of data necessitates further research to elucidate the pathophysiological connection between depression and cardiac diseases in the presence of N-terminal pro-brain natriuretic peptide (NT-proBNP). Therefore, the current systematic review investigated the clinical significance of NT-proBNP as a predictive biomarker in cardiac patients with depressive symptoms. Methods: Two researchers independently performed an extensive search of published literature from inception until April 2024 on PubMed, Web of Science, and Cochrane Library in accordance with the PRISMA guidelines. From a total of 452 records, 29 articles were eligible for full-text review, whereof, data from 14 articles were systematically collated. Based on the Newcastle-Ottawa Scale (NOS) criteria, all studies earned 6-9 stars and were of good quality. Results: Among a total population of 4,035, male patients were predominantly higher ( Conclusion: The presence of elevated NT-proBNP in depression demonstrated adverse cardiovascular outcomes and played a crucial role in predicting the clinical prognosis. Future NT-proBNP studies with predefined follow-up period at different time intervals, and in clinically depressed patients are highly recommended. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier (CRD42024536115).
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