ArticlebioRxiv : the preprint server for biology2025
New alleles of
Madhulika Rai, Prince Okah, Shefali A Shefali, Alexander J Fitt, Michael Z Shen, Mandkhai Molomjamts, Robert Pepin, Travis Nemkov, Angelo D'Alessandro, Jason M Tennessen
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Madhulika RaiDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Prince OkahDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Shefali A ShefaliDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Alexander J FittDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Michael Z ShenDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Mandkhai MolomjamtsDepartment of Biology, Indiana University, Bloomington, IN 47405, USA.
Robert PepinDepartment of Chemistry, Indiana University, Bloomington, IN 47405, USA.
Travis NemkovDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Colorado, USA.ORCID 0000-0001-8566-7119 Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Colorado, USA.ORCID 0000-0002-2258-6490 Funding
FLYBASE: A DROSOPHILA RELATIONAL DATABASEP41HG000739 · NHGRI · HARVARD UNIVERSITY · PI GELBART, WILLIAM MARTIN · 1992 to 2014
$56.6MResource Project CoreU41HG000739 · NHGRI · HARVARD UNIVERSITY · PI PERRIMON, NORBERT · 2014 to 2022
$32.3MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MDROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4MA Drosophila Model for the Regulation of Aerobic GlycolysisR35GM119557 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Jason Michael Tennessen · 2016 to 2026
$4.7MNHGRI NIH HHS P41 HG000739NHGRI NIH HHS U41 HG000739NIGMS NIH HHS R35 GM119557NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itselfAbstract
D-2-hydroxyglutarate (D-2HG) is a potent oncometabolite capable of disrupting chromatin architecture, altering metabolism, and promoting cellular dedifferentiation. As a result, ectopic D-2HG accumulation induces neurometabolic disorders and promotes progression of multiple cancers. However, the disease-associated effects of ectopic D-2HG accumulation are dependent on genetic context. Specifically, neomorphic mutations in the mammalian genes
Indexed as
D-2HGD2hgdhd-2-hydroxyglutarate dehydrogenaseDrosophila melanogastermetabolismoncometabolite
Identifiers
PMID40236175
PMCPMC11996423
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390