Evidence map›Paper›PMID 40236168›Full record

ArticlebioRxiv : the preprint server for biology2025

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis.

K Huang, T Miao, E Dantas, M Han, Y Hu, K Wang, J Sanford, M Goncalves, N Perrimon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

K HuangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-1866-8407
T MiaoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0002-0634-7377
E DantasDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-4934-4632
M HanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0009-0004-1952-8056
Y HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-1494-1402
K WangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
J SanfordDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0001-6054-9685
M GoncalvesDivision of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-0784-9248
N PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0001-7542-472X

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
CANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657k
NCI NIH HHS OT2 CA278685NCI NIH HHS P01 CA120964
6 · The paper itself

Abstract

Tumors require metabolic adaptations to support their rapid growth, but how they influence lipid metabolism in distant tissues remains poorly understood. Here, we uncover a novel mechanism by which gut tumors in adult flies reprogram lipid metabolism in distal hepatocyte-like cells, known as oenocytes, to promote tracheal development and tumor growth. We show that tumors secrete a PDGF/VEGF-like factor, Pvf1, that activates the TORC1-Hnf4 signaling pathway in oenocytes. This activation enhances the production of specific lipids, including very long-chain fatty acids and wax esters, that are required for tracheal growth surrounding the gut tumor. Importantly, reducing expression in oenocytes of either the transcription factor

Identifiers

PMID40236168
PMCPMC11996582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.