ArticlebioRxiv : the preprint server for biology2025
Associations between fluid biomarkers and PET imaging ([
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPositron Emission Tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigate the relationship between SV2A PET and CSF synaptic protein changes of AD patients.
methodTwenty-one participants with early AD and 7 cognitively normal (CN) individuals underwent [
resultsIn the AD group, higher levels of syntaxin-7 and PEBP-1 were associated with lower global synaptic density. In the total sample, lower global synaptic density was associated with higher levels of AP2B1, neurogranin, γ-synuclein, GDI-1, PEBP-1, syntaxin-1B, and syntaxin-7 but not with the levels of the neuronal pentraxins or 14-3-3 zeta/delta.
conclusionReductions of synaptic density found in AD compared to CN participants using [
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