ArticlebioRxiv : the preprint server for biology2025
Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leptospirosis is a neglected zoonotic disease caused by pathogenic Author Summary: Leptospirosis is an infectious disease with approximately one million new cases annually and is responsible for about 5% of deaths, particularly in underdeveloped countries. Our objective is to understand the immune response in leptospirosis, specifically the role of the Complement C3 protein. In this study, we observed that C3 deficiency is associated with a higher renal leptospiral load and an increased incidence of renal fibrosis after one month of chronic infection. Notably, C3 also influences the differentiation of helper and cytotoxic T lymphocytes into effector cells, potentially contributing to the increased severity of chronic leptospirosis observed in C3-deficient animals.
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