ArticlebioRxiv : the preprint server for biology2025
How much is Transcription-associated Mutagenesis Driving tRNA Microevolution?
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transfer RNAs (tRNAs) are among the most highly conserved and frequently transcribed genes. Recent studies have identified transcription-associated mutagenesis (TAM) as a significant contributor to sequence variation around tRNA loci. However, the extent to which TAM drives allelic variation in tRNAs remains unclear, largely due to the confounding effects of strong selection pressures to maintain their structural integrity. This complexity arises because TAM-induced mutations primarily involve nucleotide transitions, which tend to preserve base-pairing stability. To address this dichotomy at the population level, we analyzed tRNA allelic variation in contemporary
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