Evidence map›Paper›PMID 40235980›Full record

ArticlebioRxiv : the preprint server for biology2025

Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinoma.

Hari Shankar Sunil, Jean Clemenceau, Isabel Barnfather, Sumanth R Nakkireddy, Anthony Grichuk, Luke Izzo, Bret M Evers, Lisa Thomas, Indhumathy Subramaniyan, Li Li and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Hari Shankar SunilORCID 0000-0002-4416-3720
Isabel BarnfatherORCID 0009-0007-3071-963X
Sumanth R Nakkireddy
Bret M Evers
Lisa Thomas
Indhumathy Subramaniyan
Li Li
William T Putnam
Jingfei Zhu
Barrett Updegraff
John D Minna
Ralph J DeBerardinisORCID 0000-0002-2705-7432
Tae Hyun Hwang
Kathryn A O'DonnellORCID 0000-0003-2215-1064

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
Pro-tumor functions of neutrophils in squamous cell lung cancerR01CA244841 · NCI · UNIVERSITY OF UTAH · PI OLIVER, TRUDY GALE · 2020 to 2024
$2.0M
The role of translation initiation factor eIF5B in lung cancer pathogenesisR01CA273585 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2023 to 2026
$1.9M
Identifying Mechanisms of Sox2-Driven Squamous Cell Lung CancerR01CA187457 · NCI · UNIVERSITY OF UTAH · PI OLIVER, TRUDY GALE · 2014 to 2018
$1.5M
Translational Cancer Biology (TCB) T32 Training ProgramT32CA291654 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Rolf A Brekken, Jerry William Shay · 2024 to 2026
$1.2M
NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA187457NCI NIH HHS R01 CA244841NCI NIH HHS R01 CA273585NCI NIH HHS T32 CA291654
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. Existing therapeutic options have limited efficacy, particularly for lung squamous cell carcinoma (LUSC), underscoring the critical need for the identification of new therapeutic targets. We previously demonstrated that the Transmembrane Serine Protease

Identifiers

PMID40235980
PMCPMC11996519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.