Evidence map›Paper›PMID 40235976›Full record

ArticlebioRxiv : the preprint server for biology2025

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas.

Christian Felipe Ruiz, Xiangyu Ge, Rylee McDonnell, Sherry S Agabiti, Daniel C McQuaid, Andy Tang, Meera Kharwa, Jennifer Goodell, Rocío Del M Saavedra-Peña, Allison Wing and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Christian Felipe Ruiz
Xiangyu Ge
Rylee McDonnell
Sherry S Agabiti
Daniel C McQuaid
Andy Tang
Meera Kharwa
Jennifer Goodell
Rocío Del M Saavedra-Peña
Allison Wing
Guangtao Li
Natasha Pinto Medici
Marie E Robert
Rohan R Varshney
Michael C Rudolph
Fred S Gorelick
John Wysolmerski
John D Haley
Matthew S Rodeheffer
Mandar Deepak MuzumdarORCID 0000-0001-7424-7223

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
PMCA2 regulates mammary gland involution and breast cancerR01HD076248 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2014 to 2024
$4.4M
Dietary fatty acids drive pancreatic cancer developmentR01CA276108 · NCI · YALE UNIVERSITY · PI Mandar Deepak Muzumdar · 2023 to 2026
$2.6M
Defining tumor cell and host adaptations in cancer progressionDP2CA248136 · NCI · YALE UNIVERSITY · PI MUZUMDAR, MANDAR DEEPAK · 2019 to 2019
$2.5M
Heterodimerization of the Calcium-sensing receptor with the GabaB receptors in the breast.R01HD100468 · NICHD · YALE UNIVERSITY · PI WYSOLMERSKI, JOHN J · 2020 to 2024
$2.1M
NCI NIH HHS DP2 CA248136NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA276108NICHD NIH HHS R01 HD076248NICHD NIH HHS R01 HD100468NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM136651
6 · The paper itself

Abstract

High-fat diet (HFD) intake has been linked to an increased risk of pancreatic ductal adenocarcinoma (PDAC), a lethal and therapy-resistant cancer. However, whether and how specific dietary fats drive cancer development remains unresolved. Leveraging an oncogenic

Identifiers

PMID40235976
PMCPMC11996499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.