ArticleNeuropsychiatric disease and treatment2025
Correlation Between Systemic Immune Inflammatory Index and Suicidal Attempt in Patients with First-Episode Untreated Depression and its Risk Factors.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Mood stabilizers and systemic inflammatory burden in euthymic patients with bipolar disorder: a comparative study of lithium and valproate.Psychopharmacology · 2026Article
- Exploring potential value of neutrophil extracellular traps in major depressive disorder.Frontiers in immunology · 2026Article
- The relationship between suicidal behavior and hematological inflammatory parameters: a retrospective cohort study.Frontiers in psychiatry · 2026Article
- Gender differences in the association between pan-immune-inflammation value and probable depression: A cross-sectional study.PloS one · 2025Article
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7 authors.
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Abstract
Objective: To examine the relationship between the systemic immune inflammatory index (SII) and suicide attempts (SA) in individuals experiencing their first episode of major depressive disorder (MDD). Methods: A retrospective analysis of 338 MDD patients (2020-2023) at the First Affiliated Hospital of Wannan Medical College and 76 healthy controls (HC) was conducted. MDD patients were categorized based on their history of SA. Differences in SII and clinical characteristics were analyzed, and a receiver operating characteristic (ROC) curve was used to determine the optimal SII cutoff for predicting SA. Binary logistic regression identified independent risk factors associated with SA. Results: MDD patients exhibited higher levels of neutrophils, platelets, and SII compared to HC (all Conclusion: SII represents a cost-effective and accessible method for evaluating suicide risk in patients with MDD.
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