Evidence map›Paper›PMID 40235959›Full record

ArticleBrain communications2025

Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates.

Koichi Uramaru, Hiroki Abe, Waki Nakajima, Wataru Ota, Michiaki Suzuki, Osamu Yokoyama, Tetsuya Yamamoto, Yukio Nishimura, Takuya Takahashi

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Koichi UramaruDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0009-0004-4006-8891
Hiroki AbeDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Wataru OtaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0000-0003-4478-5471
Michiaki SuzukiNeural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.ORCID https://orcid.org/0000-0003-0725-0515
Osamu YokoyamaNeural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Tetsuya YamamotoDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yukio NishimuraNeural Prosthetics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.ORCID https://orcid.org/0000-0003-3479-2483
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.ORCID https://orcid.org/0000-0001-6523-0622

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While spinal cord injury (SCI) aggravates the quality of life in humans by severe paralysis, clinical intervention to promote functional recovery from SCI is limited. We recently identified a small compound, edonerpic maleate (edonerpic MA), which accelerates training-dependent motor functional recovery from brain damage in rodents (cryo-genic cortical injury) and non-human primates (internal capsule haemorrhage) by the facilitation of experience-dependent synaptic trafficking of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. In the present study, we investigated whether edonerpic MA accelerates functional recovery after SCI in non-human primates. Six adult monkeys (

Indexed as

AMPA receptoredonerpic maleatespinal cord injury

Identifiers

PMID40235959
PMCPMC11997772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.