ArticleEClinicalMedicine2025
Dynamics of serum testosterone and biological aging in men: insights from Chinese, American, and British populations.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.Genes & diseases · 2026Review
- Early-Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection.MedComm · 2026Review
- Association between obstructive sleep apnea and sex hormones in U.S. adult males: a population-based study.Sexual medicine · 2026Article
- Review
- Inverted U-shaped relationship between diverticular width and gastrointestinal bleeding in symptomatic Meckel's diverticulum children: a retrospective single-center study.Frontiers in pediatrics · 2026Article
- Cerebral perfusion pressure trajectories and cumulative exposure metrics predict in-hospital mortality in acute brain injury.Frontiers in medicine · 2026Article
- Research Progress on the Interaction Between SIRT1 and Mitochondrial Biochemistry in the Aging of the Reproductive System.Biology · 2025Review
- The human biological clock and aging-a comprehensive approach integrating reductionism, holism, and geromedicine for proactive healthspan strategies.Frontiers in aging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Biological age (BA) is considered a better predictor of aging than chronological age (CA). BA acceleration was defined as the disparity between BA and CA. However, there has been inconclusive evidence on whether BA acceleration might be reversed by increased total testosterone (TT). The goal of this cross-sectional study was to investigate the relationship between TT and BA acceleration. Methods: Klemera and Doubal method biological age (KDM-BA) was employed as an indicator of BA in this study. This study involved participants of three ancestries from five cohorts, including the National Health and Nutrition Examination Survey (NHANES, recruited between 1 January 2011 and 31 December 2016), West China Health and Aging Trend (WCHAT, recruited between 1 January 2018 and 31 December 2018), West China Natural Population Cohort Study (WCNPCS, recruited between 1 January 2019 and 31 December 2020), UK Biobank (UKB, recruited between 3 March 2016 and 1 October 2020), and the West China Hospital robot-assisted radical prostatectomy (RARP) cohort (recruited between 1 January 2017 and 31 December 2023). Association between serum TT and BA acceleration were assessed by multivariable linear regression in NHANES, WCHAT, and WCNPCS. Change-to-change analysis was performed to evaluate the association between the dynamic of serum TT and BA acceleration in the UKB. 38 prostate cancer patients underwent adjuvant androgen deprivation therapy (ADT) were included to exploring whether ADT deteriorates BA acceleration. Findings: A total of 6976, 2080, 2133, and 6058 participants from NHANES, WCHAT, WCNPCS, and UKB, respectively, were included in the study. Higher serum TT was consistently associated with attenuated BA acceleration across NHANES, WCHAT, and WCNPCS. In UKB, Box-Cox with negatives allowed (BCN)-transformed relative TT change was significantly associated with decreased BCN-transformed BA acceleration change (β: -0.047, 95% CI: -0.057 to -0.038). The results were remained robust in the stratification analysis, restricted cubic spline regression (RCS), and sensitivity analysis. The pre-and-post ADT paired test further indicated the deprivation of TT accelerated biological aging of prostate cancer patients. Interpretation: This study reveals that higher serum TT was associated with reduced biological aging. Men with increased serum TT on repeat testing demonstrated reduced BA acceleration. Comparison of men with prostate cancer revealed advanced BA acceleration after receiving ADT. This study suggests TT may be a reasonable indicator for biological aging. Funding: National key research and development program of China, Programs from Science and Technology Department of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.