ArticleQuantitative imaging in medicine and surgery2025
Quantitative vessel density around foveal avascular zone as a potential imaging biomarker for detecting central nervous system injury in Wilson's disease: an optical coherence tomography angiography study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Studies have confirmed that optical coherence tomography angiography (OCTA) can detect early retinal microvascular impairment in many diseases. However, as far as we know, only one study has found retinal and optic disc microcirculation changes in Wilson's disease (WD) by OCTA. The purpose of our study was to evaluate the OCTA parameters in WD. Methods: We performed a cross-sectional study at the First Affiliated Hospital of Guangdong Pharmaceutical University between June 2021 and April 2022. A total of 42 WD patients and 40 gender- and age-matched healthy controls (HEC) were recruited in this study. WD patients were divided into neurological form (NWD) and hepatic form (HWD) of the disease. All participants underwent retinal OCTA to assess the superficial vessel density (VD), deep VD, and foveal avascular zone (FAZ) parameters. The FAZ parameters included the area in mm Results: WD patients comprised 21 females and 21 males, with mean age of 30.54±9.83 years. HEC comprised 16 females and 24 males, with mean age of 30.42±7.37 years. NWD had smaller FD-300 (51.67%±5.29% Conclusions: Our study indicated that OCTA may be a useful tool for detecting central nervous system (CNS) injury in WD. We speculate that the decrease of FD-300 may be a sign of CNS injury in WD.
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