ArticleQuantitative imaging in medicine and surgery2025
Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanopriming by vascular stiffness and phenotypic reprogramming by disturbed flow: mechanobiology and clinical translation in atherosclerosis.Frontiers in cardiovascular medicine · 2026Pooled it
- Association and Risk-Stratification Value of the Positive Remodeling Index of Middle Cerebral Artery Atherosclerotic Plaques for Perforator-Territory Infarction Based on High-Resolution Magnetic Resonance Imaging.Revista de neurologia · 2026Article
- Atherosclerotic middle cerebral artery stenosis: adjacent arterial geometry, hemodynamics and plaque features.Japanese journal of radiology · 2026Article
- Lack of Anterior Communicating Artery Is Associated with Symptomatic Middle Cerebral Artery Atherosclerosis.Biomedicines · 2026Article
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12 authors.
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Abstract
Background: Hemodynamics is crucial for the assessment of atherosclerotic development. However, flow alterations due to plaque existence and increased plaque number in different intracranial arterial segments have not been fully understood. This study aimed to investigate the relationship of wall shear stress (WSS) parameters between middle cerebral arteries (MCAs) with and without plaque and explore the potential discrepancy between multiple- and single-plaque existence. Methods: Consecutive patients with MCA atherosclerosis were recruited and underwent four-dimensional (4D) flow magnetic resonance imaging (MRI) and three-dimensional (3D) vessel wall imaging (VWI). Time-averaged WSS (TAWSS), time-averaged WSS coefficient variation (TAWSSCV), and oscillatory shear index (OSI) were measured at five cross-sectional slices [initial, upstream, the most narrowed lumen (MNL), downstream, and terminal] of plaque and reference (REF) sites to describe lesion-level hemodynamics. Segment-level hemodynamics of M1 and M2 segments were also analyzed. MCA geometry and plaque characteristics were calculated. The MCAs were then classified into four groups according to plaque presence in different segments: Group I, without plaque; Group II, with plaque only in M1; Group III, with plaque in both M1 and M2; Group IV, with plaque only in M2. The above parameters were compared in MCA with and without plaque as well as single- and multiple-plaque (≥2) MCAs. Results: A total of 150 MCAs with 231 plaques from 79 patients were investigated. TAWSS Conclusions: Hemodynamic alterations are observed under the impacts of atherosclerosis and are different between M1 plaque and M2 plaque. Single- and multiple-plaque MCAs exhibit different geometry, plaque characteristics, and hemodynamics, and these vary according to segments. The interplay of arterial segment, plaque number, and characteristics as well as hemodynamics could provide insight for the mechanisms of atherosclerotic existence.
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